caa a22 4500 477072380 CHVBK 20180405111429.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00051109 doi (NATIONALLICENCE)springer-10.1007/BF00051109 Delay by a calcium antagonist, amlodipine, of the onset of primary ventricular fibrillation in myocardial ischemia [Elektronische Daten] [Quadiri Timour, Bernard Bui-Xuan, Georges Faucon, Jean-François Aupetit] Summary: Calcium antagonists have been reported to counteract the increase by ischemia of vulnerability to ventricular fibrillation. This ability might be especially of interest in the prevention of sudden death subsequent to a major, but transitory, inadequacy between myocardial oxygen requirements and available coronary blood flow produced by exercise, emotion, etc., because death is then not related to irreversible damage of myocardial fibers. This study has been undertaken to examine the protective effect of a calcium antagonist on an animal model of this type of ischemia. This model used complete, but transient occlusion of the left anterior descending coronary artery near its origin during pacing at a constant high rate (180 beats/min) in anesthetized, open-chest pigs, most often resulting in fibrillation within 1-2 minutes after a progressive fall of the electrical fibrillation threshold. Amlodipine was the preferred calcium antagonist for this study because it is only moderately negatively inotropic. The results of the preventive administration of amlodipine was assessed by the time to onset of fibrillation. Amlodipine 0.30 mg/kg prolonged this time by 50-100% (p < 0.05) without appreciable impairment of blood pressure or myocardial contractility. Concurrently, amlodipine delayed the shortening of the monophasic action potential duration, the lengthening of conduction time, and the alterations of ST segments and T waves linked to ischemic depolarization. Consequently, when given experimentally before the occurrence of major, but transitory ischemia, amlodipine protected against fibrillation. Similarly, in clinical settings it ought to delay sudden death that may occur as a result of a major but transitory inadequacy between myocardial oxygen requirements and available coronary blood flow. Kluwer Academic Publishers, 1996 amlodipine nationallicence dihydropyridines nationallicence calcium antagonists nationallicence ischemic ventricular fibrillation nationallicence transitory myocardial ischemia nationallicence Timour Quadiri Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut Bui-Xuan Bernard Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut Faucon Georges Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut Aupetit Jean-François Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/4(1996-09-01), 447-454 0920-3206 10:4<447 1996 10 10557 https://doi.org/10.1007/BF00051109 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00051109 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Timour Quadiri Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut NATIONALLICENCE 700 1- Bui-Xuan Bernard Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut NATIONALLICENCE 700 1- Faucon Georges Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut NATIONALLICENCE 700 1- Aupetit Jean-François Department of Medical Pharmacology, Cl. Bernard University, Lyon, France aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/4(1996-09-01), 447-454 0920-3206 10:4<447 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer