caa a22 4500 477072429 CHVBK 20180405111430.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF00051108 doi (NATIONALLICENCE)springer-10.1007/BF00051108 Calcium antagonists and endothelial function: Focus on nitric oxide and endothelin [Elektronische Daten] [Théophile Godfraind, Salvatore Salomone] Summary: This paper reports on some interactions of calcium antagonists with nitric oxide and endothelin. It reviews evidence showing that the vasorelaxant action of calcium antagonists is facilitated by nitric oxide and describes the mechanism of this modulation. The interaction of calcium antagonists with endothelin is examined considering functions and production of the peptide. Among the functions examined, attention is drawn to the potentiation of responses to vasoconstrictors evoked by low threshold concentrations of endothelin, an action that could be important in pathology. The production of endothelin is increased by a high-salt diet in spontaneous hypertensive stroke-prone rats, this increased production, related to the overexpression of prepro ET-1mRNA, is responsible for cardiovascular hypertrophy and is blunted, in a blood pressure-unrelated manner, by the calcium antagonist lacidipine. At the same dosage regimen, lacidipine inhibits the hypertrophy of the cardiovascular system evoked by a high-salt diet. Kluwer Academic Publishers, 1986 calcium antagonists nationallicence calcium channel blockers nationallicence verapamil nationallicence diltiazem nationallicence isradipine nationallicence lacidipine nationallicence nisoldipine nationallicence nitric oxide nationallicence endothelin nationallicence hypertension nationallicence human coronary artery nationallicence human coronary vein nationallicence Godfraind Théophile Laboratoire de Pharmacologie, Université Catholique de Louvain, Avenue Hippocrate, Brussels, Belgium aut Salomone Salvatore Laboratoire de Pharmacologie, Université Catholique de Louvain, Avenue Hippocrate, Brussels, Belgium aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/4(1996-09-01), 439-446 0920-3206 10:4<439 1996 10 10557 https://doi.org/10.1007/BF00051108 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00051108 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Godfraind Théophile Laboratoire de Pharmacologie, Université Catholique de Louvain, Avenue Hippocrate, Brussels, Belgium aut NATIONALLICENCE 700 1- Salomone Salvatore Laboratoire de Pharmacologie, Université Catholique de Louvain, Avenue Hippocrate, Brussels, Belgium aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/4(1996-09-01), 439-446 0920-3206 10:4<439 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer