caa a22 4500 477072534 CHVBK 20180405111430.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF00050998 doi (NATIONALLICENCE)springer-10.1007/BF00050998 Antioxidant status of hypercholesterolemic patients treated with LDL apheresis [Elektronische Daten] [Sylvie Lepage, Dominique Bonnefont-Rousselot, Eric Bruckert, Brigitte Bourely, Marie-Chantal Jaudon, Jacques Delattre, Ubald Assogba] Summary: Oxidation of low density lipoprotein is involved in the pathogenesis of atherosclerosis. Epidemiological studies suggest a negative correlation between the occurrence of cardiovascular diseases and blood concentrations of lipophilic antioxidants such as vitamins A and E and β-carotene. Trace elements, such as selenium, zinc, and copper, are involved in the activity of the antioxidant enzymes glutathione peroxidase and superoxide dismutase. The aim of this study was to determine the antioxidant and trace element status of patients with severe hypercholesterolemia who had been treated with dextran-sulphate low-density lipoprotein apheresis in comparison with two control populations, normocholesterolemic subjects and untreated hypercholesterolemic patients. Our results showed that, patients treated with LDL apheresis, compared with normocholesteromic subjects, were not deficient in vitamin E, β-carotene, and copper, but had low plasma levels of selenium, zinc, and vitamin A. The low selenium and vitamin A levels were due to the LDL-apheresis treatment, and the hypercholesterolemia might have provoked the low plasma levels of zinc. This study pointed out the potential benefits of supplemental selenium, zinc, and vitamin A in patients being treated with LDL apheresis. Kluwer Academic Publishers, 1996 antioxidants nationallicence vitamins nationallicence trace elements nationallicence hypercholesterolemia nationallicence LDL apheresis nationallicence Lepage Sylvie Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut Bonnefont-Rousselot Dominique Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut Bruckert Eric Service d'Endocrinologie et Métabolisme, Hôpital Pitié-Salpêtrière, Paris, France aut Bourely Brigitte Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut Jaudon Marie-Chantal Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut Delattre Jacques Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut Assogba Ubald Centre Hémobiologie-Transfusion de Paris-Centre, Hôpital Pitié-Salpêtrière, Paris, France aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/5(1996-11-01), 567-571 0920-3206 10:5<567 1996 10 10557 https://doi.org/10.1007/BF00050998 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00050998 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lepage Sylvie Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Bonnefont-Rousselot Dominique Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Bruckert Eric Service d'Endocrinologie et Métabolisme, Hôpital Pitié-Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Bourely Brigitte Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Jaudon Marie-Chantal Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Delattre Jacques Laboratoire de Biochimie, Hôpital Pitié-Salpêtrière, Paris, France aut NATIONALLICENCE 700 1- Assogba Ubald Centre Hémobiologie-Transfusion de Paris-Centre, Hôpital Pitié-Salpêtrière, Paris, France aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/5(1996-11-01), 567-571 0920-3206 10:5<567 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer