caa a22 4500 477072550 CHVBK 20180405111430.0 cr unu---uuuuu 170330e19961101xx s 000 0 eng 10.1007/BF00051001 doi (NATIONALLICENCE)springer-10.1007/BF00051001 Prevention by cromakalim of spontaneously occurring cardiac necroses in polymyopathic hamsters [Elektronische Daten] [Gaëtan Jasmin, Libuse Proschek] Summary: Previous studies on the heart necrotizing process at early stages of the hamster polymyopathy have led us to believe that this hereditary disease derives from a defective transmembrane ion flux resulting in myocardial Ca2+ overload. On the other hand, certain K+ ATP channel openers were shown to prevent cytosolic Ca2+ accumulation in ischemic hearts. Therefore, we investigated the potential beneficial effect of chronic treatment with cromakalim (CR) on the development of necrotic changes in hamster myopathic hearts. Young cardiomyopathic (CM) hamsters were treated parenterally with CR over 4 consecutive weeks. The K+ ATP opener was dissolved in 5% DMSO and injected twice daily (sc and ip alternatively) at a dose level of 2.5 mg/kg per injection. Microscopic readings were carried out in staged serial paraffin sections of heart ventricles, the diaphragm, and tongue, with all tissues freshly taken at autopsy. In comparison with control untreated hearts, which exhibit numerous nécrotic calcific foci, only minute myolytic lesions were found in 5 of 12 hamsters hearts receiving CR (p<0.0001). Interestingly, the dystrophic process in the tongue was significantly less severe (p<0.0004) in CR-treated animals. These observations provide evidence for the first time that in vivo sustained treatment with a K+ ATP opener exerts cardioprotection upon development of the hamster hereditary cardiomyopathy. Kluwer Academic Publishers, 1996 K+ATP channels nationallicence cromakalim nationallicence cardioprotection nationallicence hamster cardiomyopathy nationallicence Jasmin Gaëtan Département de Pathologie, Université de Montréal, Montréal, Québec, Canada aut Proschek Libuse Département de Pathologie, Université de Montréal, Montréal, Québec, Canada aut Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/5(1996-11-01), 587-591 0920-3206 10:5<587 1996 10 10557 https://doi.org/10.1007/BF00051001 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00051001 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jasmin Gaëtan Département de Pathologie, Université de Montréal, Montréal, Québec, Canada aut NATIONALLICENCE 700 1- Proschek Libuse Département de Pathologie, Université de Montréal, Montréal, Québec, Canada aut NATIONALLICENCE 773 0- Cardiovascular Drugs and Therapy Kluwer Academic Publishers 10/5(1996-11-01), 587-591 0920-3206 10:5<587 1996 10 10557 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer