caa a22 4500 477074006 CHVBK 20180405111434.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF02252560 doi (NATIONALLICENCE)springer-10.1007/BF02252560 Distribution and quantitative characterization of NADPH-diaphorase-reactive neurons in analgesic zones of the rat midbrain [Elektronische Daten] [A. Pilyavskii, V. Maiskii, N. Hariri, G. Peker, N. Bulgakova] The distribution of nitric oxide synthase (nicotinamide adenine dinucleotide phosphate diaphorase, NADPH-d)-containing neurons in the rat midbrain was studied. We found that NADPH-d-reactive neurons were predominantly concentrated in the dorsolateral part of the periaqueductal gray (PAG) and the dorsal raphe nucleus, which are implicated in the control of nociceptive transmission. Such neurons were also present in the supraoculomotor cap and laterodorsal tegmental nuclei. In the dorsolateral part ofPAG, the moderately stained small fusiform cells were revealed. In the dorsal raphe nucleus and laterodorsal tegmental nuclei, the densely stained multipolar or oval cells of larger size dominanted. The NADPH-d-reactive cells were not found in the ventrolateral part of central gray, which is considered the main source of antinociceptive descending influences. Quantitative analysis of histochemically revealed neurons showed that their number is somewhat higher in the caudal parts of dorsolateral central gray and considerably higher in the rostral regions of some dorsal raphe subnuclei. This peculiarity was expressed in significant accumulation of the NADPH-d-reactive neurons at the midbrain levels from Fr −7.6 to −8.0. The possible involvement of the NO-synthase-containing class of neurons in the functional organization of analgesic zones and formation ofPAG antinociceptive output signals is discussed. Plenum Publishing Corporation, 1997 Pilyavskii A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut Maiskii V. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut Hariri N. Ege University, School of Medicine, Izmir, Turkey aut Peker G. Ege University, School of Medicine, Izmir, Turkey aut Bulgakova N. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/1(1996-01-01), 27-35 0090-2977 28:1<27 1996 28 11062 https://doi.org/10.1007/BF02252560 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02252560 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pilyavskii A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Maiskii V. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Hariri N. Ege University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Peker G. Ege University, School of Medicine, Izmir, Turkey aut NATIONALLICENCE 700 1- Bulgakova N. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/1(1996-01-01), 27-35 0090-2977 28:1<27 1996 28 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer