caa a22 4500 477074065 CHVBK 20180405111434.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF02252562 doi (NATIONALLICENCE)springer-10.1007/BF02252562 Effect of indomethacin-induced inhibition of arachidonic acid metabolism on the development of cardiogenic reflexes [Elektronische Daten] [V. Pavlyuchenko, A. Moibenko] In acute experiments on anesthetized cats, afferent spike activity from the parasympathetic (vagal) and sympathetic cardiac nerves, ECG, and cardiodynamic indices were recorded. The effects of indomethacin-induced blockade of cyclo-oxygenase pathway in metabolism of arachidonic acid on the development of cardiogenic reflex responses after intracoronary injections of veratrine, bradykinin, or prostacyclin were tested. It was found that after indomethacin injection depressor cardiogenic vagal reflexes, evoked by veratrine or bradykinin administrations, became significantly suppressed or practically disappeared. This was accompanied by a drop in the frequency of afferent vagal activity in the cardiac nerves. This effect could be observed throughout the entire period of influence of indomethacin (about 2 h after its injection). Veratrine or bradykinin, being injected simultaneously with prostacyclin, provided faster partial recovery of depressor responses (at 1 h) and promoted some activation of vagal cardiac nerves, despite the effect of indomethacin. Injection of indomethacin did not change the pattern of sympathetic afferent activity. It is suggested that the main derivative of cyclo-oxygenase pathway of arachidonic acid metabolism, prostacyclin, is able to modulate vagal nervous activity at the level of afferent structures in the heart. Prostacyclin may appear a humoral component of cardiogenic depressor reflexes of a vagal nature. Plenum Publishing Corporation, 1997 Pavlyuchenko V. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut Moibenko A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/1(1996-01-01), 41-48 0090-2977 28:1<41 1996 28 11062 https://doi.org/10.1007/BF02252562 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02252562 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pavlyuchenko V. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Moibenko A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/1(1996-01-01), 41-48 0090-2977 28:1<41 1996 28 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer