caa a22 4500 477074103 CHVBK 20180405111434.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02262774 doi (NATIONALLICENCE)springer-10.1007/BF02262774 Parameters of conduction via afferent nerve fibers in mice with streptozotocin-induced and genetically determined diabetes [Elektronische Daten] [E. Kostyuk, N. Bulgakova, D. Vasilenko] The parameters of conduction via afferent nerve fibers were studied in mice with streptozotocin-induced and genetically determineddiabetes mellitus (9- to 12-week-old animals; streptozotocin was injected into 5-week-old mice). Recording of spinal cord dorsal surface potentials evoked by stimulation of the sciatic nerve showed that within the studied time interval the mice of the two diabetic groups were characterized by a moderate decrease (by 7.9% and 5.8%, on average) in the conduction velocity for afferent volleys (measured according to the delay of the peak of positivity of a volley) and by a considerable increase in the duration of the positive phase of these volleys (by 36% and 33%, respectively, as compared with the values in intact animals). Therefore, the population of relatively "slow” group A afferent fibers becomes noticeably larger in the sciatic nerve of diabetic mice even at early stages of the pathology, but at the same time a considerable amount of the fastest-conducting (about 45-60 m/sec) fibers is still preserved. The changes in mice with diabetes of different etiology were very similar, in spite of different hyperglycemia levels in these groups. Possible factors determining diabetes-induced modifications of the conduction velocity via the nerve fibers are discussed. Plenum Publishing Corporation, 1997 Kostyuk E. Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut Bulgakova N. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut Vasilenko D. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/4-5(1996-07-01), 135-139 0090-2977 28:4-5<135 1996 28 11062 https://doi.org/10.1007/BF02262774 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02262774 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kostyuk E. Institute of Endocrinology and Metabolism, Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Bulgakova N. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Vasilenko D. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/4-5(1996-07-01), 135-139 0090-2977 28:4-5<135 1996 28 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer