caa a22 4500 47707412X CHVBK 20180405111435.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02262773 doi (NATIONALLICENCE)springer-10.1007/BF02262773 Postsynaptic mechanisms of induction of NMDA-dependent long-term post-tetanic potentiation of synaptic transmission [Elektronische Daten] [I. Abramets, I. Samoilovich, N. Kharin] Experiments on hippocampus slices of rats showed that the pattern of induction of long-term post-tetanic potentiation of synaptic transmission is determined by the frequency of tetanic stimulation of Schaffer collaterals. With their high-frequency (>10/sec) stimulation, a phase of reversible increase in the amplitude of population EPSP (pEPSP) is observed within the initial 30-min-long interval; it is related to an increase in the intracellular Ca2+ concentration resulting from simultaneous activation of NMDA and metabotropic glutamate receptors and voltage-activated calcium channels. With the participation of calmodulin, Ca2+ activate Ca2+-calmodulin-dependent protein kinase II. The latter phosphorylates AMPA/kainate receptors (their kainate-responsive compartments), which promotes an increase in their chemosensitivity. Under conditions of low-frequency (<10/sec) tetanic stimulation of synaptic inputs, for the same reasons, an increase in the intradendritic Ca2+ concentration exerts no expressed influence on protein kinase II, but activates calcineurin. The latter, with the involvement of other phosphoprotein phosphatases, dephosphorylates AMPA/kainate receptors and turns some of them into the refractory state; this is expressed in a reversible depression of pEPSP. After 30 min of either high-frequency, or low-frequency stimulation, a non-decremental phase of long-term post-tetanic potentiation develops, which is related to the increase in the protein kinase C activity, phosphorylation of the AMPA-responsible compartments of AMPA/kainate receptors, their rising sensitivity, and a stable increase in the pEPSP amplitude Plenum Publishing Corporation, 1997 Abramets I. Donetsk State Medical University, Ministry of Public Health of Ukraine, Ukraine aut Samoilovich I. Donetsk State Medical University, Ministry of Public Health of Ukraine, Ukraine aut Kharin N. Donetsk State Medical University, Ministry of Public Health of Ukraine, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/4-5(1996-07-01), 127-134 0090-2977 28:4-5<127 1996 28 11062 https://doi.org/10.1007/BF02262773 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02262773 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Abramets I. Donetsk State Medical University, Ministry of Public Health of Ukraine, Ukraine aut NATIONALLICENCE 700 1- Samoilovich I. Donetsk State Medical University, Ministry of Public Health of Ukraine, Ukraine aut NATIONALLICENCE 700 1- Kharin N. Donetsk State Medical University, Ministry of Public Health of Ukraine, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/4-5(1996-07-01), 127-134 0090-2977 28:4-5<127 1996 28 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer