caa a22 4500 477074154 CHVBK 20180405111435.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02262776 doi (NATIONALLICENCE)springer-10.1007/BF02262776 Acetylcholinesterase inhibition in neuromuscular synapses in different background states: model studies [Elektronische Daten] [I. Kovyazina, R. Giniatullin, E. Nikol'skii, F. Vyskochil] Using mathematical modeling of the process of generation of a miniature end-plate current (MEPC), we studied the effect of acetylcholinesterase (AChE) inhibition on the amplitude and frequency parameters of synaptic signals in the neuromuscular junction. The density of acetylcholine receptors on the postsynaptic membrane and the number of acetylcholine molecules in its quantum were varied. AChE inhibition against the background of a decreased receptor density was shown to result in a much higher increase in the amplitude of modeled MEPC than that in control and in the case of the changed transmitter amount released in the synaptic cleft. The simulation data can be used as a theoretical background for interpretation of the reason for different efficiencies of AChE inhibitors in certain pathological states of the neuromuscular apparatus. Plenum Publishing Corporation, 1997 Kovyazina I. Kazan' Institute of Biology, Russian Academy of Sciences, Russia aut Giniatullin R. Kazan' State Medical University, Russia aut Nikol'skii E. Kazan' State Medical University, Russia aut Vyskochil F. Institute of Physiology, Academy of Sciences, Prague, Czech Republic aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/4-5(1996-07-01), 145-150 0090-2977 28:4-5<145 1996 28 11062 https://doi.org/10.1007/BF02262776 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02262776 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kovyazina I. Kazan' Institute of Biology, Russian Academy of Sciences, Russia aut NATIONALLICENCE 700 1- Giniatullin R. Kazan' State Medical University, Russia aut NATIONALLICENCE 700 1- Nikol'skii E. Kazan' State Medical University, Russia aut NATIONALLICENCE 700 1- Vyskochil F. Institute of Physiology, Academy of Sciences, Prague, Czech Republic aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/4-5(1996-07-01), 145-150 0090-2977 28:4-5<145 1996 28 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer