caa a22 4500 477074316 CHVBK 20180405111435.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02262772 doi (NATIONALLICENCE)springer-10.1007/BF02262772 Selective pharmacological blocking of synaptic transmission through the parasympathetic ganglia: Effects on the cardiovascular system [Elektronische Daten] [A. Tsybenko, P. Yanchuk, L. Egorova, V. Gmiro] In acute experiments on rats and dogs, compounds IEM-1556 and IEM-1678, the blockers of transmission through the parasympathetic ganglia, reduced the negative chronotropic effect of stimulation of the vagus nerve (VN), while practically not changing the heart rate (HR). In chronic experiments on dogs, these compounds increased the HR, substantially reduced the respiratory heart arrhythmia, did not change the arterial blood pressure (AP), and reduced the chronotropic effects of VN stimulation. IEM-1556 exerted more strong and long-lasting blocking effects on vagal heart control than IEM-1678 did, but in anesthetized animals could evoke a drop in the AP. Acetylcholine, if administered during the action of the above compounds, inhibited heart activity. It is concluded that both IEM-1678 and IEM-1556 are selective parasympatholytics (although IEM-1556 may produce a side effect). The above compounds block synaptic transmission through the intracardiac parasympathetic ganglia and do not affect neuro-effector transmission in the heart. Plenum Publishing Corporation, 1997 Tsybenko A. Shevchenko State University, Kiev, Ukraine aut Yanchuk P. Shevchenko State University, Kiev, Ukraine aut Egorova L. Institute of Experimental Medicine, Russian Academy of Medical Sciences, Saint Petersburg, Russia aut Gmiro V. Institute of Experimental Medicine, Russian Academy of Medical Sciences, Saint Petersburg, Russia aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/2-3(1996-03-01), 119-125 0090-2977 28:2-3<119 1996 28 11062 https://doi.org/10.1007/BF02262772 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02262772 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tsybenko A. Shevchenko State University, Kiev, Ukraine aut NATIONALLICENCE 700 1- Yanchuk P. Shevchenko State University, Kiev, Ukraine aut NATIONALLICENCE 700 1- Egorova L. Institute of Experimental Medicine, Russian Academy of Medical Sciences, Saint Petersburg, Russia aut NATIONALLICENCE 700 1- Gmiro V. Institute of Experimental Medicine, Russian Academy of Medical Sciences, Saint Petersburg, Russia aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/2-3(1996-03-01), 119-125 0090-2977 28:2-3<119 1996 28 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer