caa a22 4500 477074324 CHVBK 20180405111435.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF02262765 doi (NATIONALLICENCE)springer-10.1007/BF02262765 Experimental model of brain amyloidosis in old rats [Elektronische Daten] [V. Frol'kis, N. Mezhiborskaya, B. Pugach, Yu. Rushkevich] An experimental model of brain amyloidosis, based on the widely known casein model, has been developed. In adult 8-10-month-old rats, the latter model reproduces amyloidosis of internal organs, but does not involve the brain. At the same time, in old (26-28-month-old) rats injection of sodium caseinate results in accumulations of amyloid not only in the vascular walls of the kidneys, heart, lien, and liver, but also in the walls of pial vessels and radial cortical arteries and, in more rare cases, in the walls of large vessels in the brain base. Together with the structural impairments, injections of sodium caseinate evoke considerable shifts of the parameters of background mass electrical activity in the basolateral amygdala, dorsal hippocampus, and parietal cortex. Relative content of slow δ and sometimes θ activity increased, while the share of high-frequency waves dropped. These changes were relatively moderate in adult rats, while they were much more pronounced in old rats. Investigation of behavioral phenomena showed that after injections of sodium caseinate the ability to memorize becomes suppressed, and manifestations of the depressive state are intensified. Combined injections of sodium caseinate and phenobollne, the stimulant of protein synthesis, resulted in the development of more intensive morphological and functional manifestations of amyloidosis in old rats. Plenum Publishing Corporation, 1997 Frol'kis V. Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut Mezhiborskaya N. Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut Pugach B. Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut Rushkevich Yu Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/2-3(1996-03-01), 63-72 0090-2977 28:2-3<63 1996 28 11062 https://doi.org/10.1007/BF02262765 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02262765 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Frol'kis V. Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Mezhiborskaya N. Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Pugach B. Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 700 1- Rushkevich Yu Institute of Gerontology, National Academy of Medical Sciences of Ukraine, Kiev, Ukraine aut NATIONALLICENCE 773 0- Neurophysiology Kluwer Academic Publishers-Plenum Publishers 28/2-3(1996-03-01), 63-72 0090-2977 28:2-3<63 1996 28 11062 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer