caa a22 4500 477075428 CHVBK 20180405111438.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF02901233 doi (NATIONALLICENCE)springer-10.1007/BF02901233 Modified DTPA, EDTA ligands and their paramagnetic metal complexes as contrast agents for MRI [Elektronische Daten] [Zhuo Renxi, Fu Gongcheng, Ouyang Ming, Zhao Xia, Lu Zhengrong] Six new aminocarboxylic ligands were synthesized by reactions of EDTA (ethylenediaminetetraacetic acid) dianhydride or DTPA (diethylenetriaminepenta—acetic acid) dianhydride and ethyl ester of serine, threonine and tyrosine. Their paramagnetic metal complexes were also synthesized. All ligands and paramagnetic metal complexes were characterized by IR spectra,1H NMR and elemental analyses. Relaxivity study showed that the metal complexes had higher relaxation effectiveness as compared to corresponding unmodified metal complexes. Imaging study of gadolinium complex of tyrosine ethyl ester modified DTPA in mice demonstrated that this metal complex could apparently increase the signal intensity of MR images. Springer, 1996 magnetic resonance imaging (MRI) nationallicence contrast agent nationallicence relaxivity nationallicence derivative of amino acid nationallicence Renxi Zhuo Department of Chemistry, Wuhan University, 430072, Wuhan, China aut Gongcheng Fu Department of Chemistry, Wuhan University, 430072, Wuhan, China aut Ming Ouyang Department of Chemistry, Wuhan University, 430072, Wuhan, China aut Xia Zhao Department of Chemistry, Wuhan University, 430072, Wuhan, China aut Zhengrong Lu Department of Chemistry, Wuhan University, 430072, Wuhan, China aut Wuhan University Journal of Natural Sciences Wuhan University 1/2(1996-06-01), 225-229 1007-1202 1:2<225 1996 1 11859 https://doi.org/10.1007/BF02901233 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02901233 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Renxi Zhuo Department of Chemistry, Wuhan University, 430072, Wuhan, China aut NATIONALLICENCE 700 1- Gongcheng Fu Department of Chemistry, Wuhan University, 430072, Wuhan, China aut NATIONALLICENCE 700 1- Ming Ouyang Department of Chemistry, Wuhan University, 430072, Wuhan, China aut NATIONALLICENCE 700 1- Xia Zhao Department of Chemistry, Wuhan University, 430072, Wuhan, China aut NATIONALLICENCE 700 1- Zhengrong Lu Department of Chemistry, Wuhan University, 430072, Wuhan, China aut NATIONALLICENCE 773 0- Wuhan University Journal of Natural Sciences Wuhan University 1/2(1996-06-01), 225-229 1007-1202 1:2<225 1996 1 11859 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer