caa a22 4500 477076173 CHVBK 20180405111439.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF02515732 doi (NATIONALLICENCE)springer-10.1007/BF02515732 Fate of a mutant emerging at the initial stage of evolution [Elektronische Daten] [Wei-Zhong Xu, Akiko Kashiwagi, Tetsuya Yomo, Itaru Urabe] A simple system was constructed and used in the experimental elucidation of the fate of a mutant emerging in a population. ThreeEscherichia coli strains having the same genetic background except for their glutamine synthetase gene were used as model competitors. The difference in the enzyme gene were introduced by random mutation. Competition between these bacterial strains was carried out and observed in a continuous liquid culture. In most cases, the competitors stably coexist either in a steady state or in an oscillating state. In addition, the competition between the strains was found to be a deterministic process and not a stochastic one. These results showed that an emerging mutant in a population, be it a closely related one to the original members, can attain a state of stable coexistence even in a homogeneous environment. The ability of each of the emerging mutants to maintain its stable coexistence with the original population gives rise to the accumulation of various mutants in a population. Therefore, evolution starts from gradual accumulation of various mutants in the population, which in turn leads to the diversification of the population. As our experimental system is a minimum model for the various competitions in the natural ecosystem, the observed competitive coexistence is proposed to be a general phenomenon in nature. Society of Population Ecology, 1996 biodiversity nationallicence competition nationallicence coexistence nationallicence continuous culture nationallicence bacterial mutants nationallicence Escherichia coli nationallicence Xu Wei-Zhong Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut Kashiwagi Akiko Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut Yomo Tetsuya Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut Urabe Itaru Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut Researches on Population Ecology Springer-Verlag 38/2(1996-12-01), 231-237 0034-5466 38:2<231 1996 38 10144 https://doi.org/10.1007/BF02515732 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02515732 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xu Wei-Zhong Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut NATIONALLICENCE 700 1- Kashiwagi Akiko Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut NATIONALLICENCE 700 1- Yomo Tetsuya Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut NATIONALLICENCE 700 1- Urabe Itaru Department of Biotechnology, Faculty of Engineering, Osaka University, 2-1 Yamadaoka, Suita, 565, Osaka, Japan aut NATIONALLICENCE 773 0- Researches on Population Ecology Springer-Verlag 38/2(1996-12-01), 231-237 0034-5466 38:2<231 1996 38 10144 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer