caa a22 4500 477079210 CHVBK 20180405111445.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF02251209 doi (NATIONALLICENCE)springer-10.1007/BF02251209 Hutton Jane Department of Statistics and Computational Mathematics and Department of Public Health, University of Liverpool, UK aut The ethics of randomised controlled trials: A matter of statistical belief? [Elektronische Daten] [Jane Hutton] This paper outlines the approaches of two apparently competing schools of statistics. The criticisms made by supporters of Bayesian statistics about conventional Frequentist statistics are explained, and the Bayesian claim that their method enables research into new treatments without the need for clinical trials is examined in detail. Several further important issues are considered, including: the use of historical controls and data routinely collected on patients; balance in randomised trials; the possibility of giving information to patients; patient choice and patient autonomy; and how widely the results of clinical trials can be used. It is concluded that good statistical techniques in the design and analysis of medical studies are essential, but the statistical school used in developing such techniques is relatively unimportant. John Wiley & Sons, Ltd., 1996 Health Care Analysis Kluwer Academic Publishers 4/2(1996-06-01), 95-102 1065-3058 4:2<95 1996 4 10728 https://doi.org/10.1007/BF02251209 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02251209 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Hutton Jane Department of Statistics and Computational Mathematics and Department of Public Health, University of Liverpool, UK aut NATIONALLICENCE 773 0- Health Care Analysis Kluwer Academic Publishers 4/2(1996-06-01), 95-102 1065-3058 4:2<95 1996 4 10728 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer