caa a22 4500 477081088 CHVBK 20180405111450.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF02722960 doi (NATIONALLICENCE)springer-10.1007/BF02722960 Inhibitory effect of tea polyphenols on histamine and leukotriene B4 release from rat peritoneal exudate cells [Elektronische Daten] [Noritaka Matsuo, Koji Yamada, Kouhei Yamashita, Kentaro Shoji, Mitsuo Mori, Michihiro Sugano] Summary: The effect of tea polyphenols on the release of chemical mediators, histamine and leukotriene B4 (LTB4), from rat peritoneal exudate cells (PEC) was studied. Among polyphenols, (−)-epigallocatechin gallate (EGCG) most strongly inhibited the histamine release from the cells stimulated with a calcium ionophore, A23187 or compound 48/80. Though (+)-catechin (C) and (−)-epicatechin (EC) had no effect, (−)-epigallocatechin (EGC) and (−)-epicatechin gallate (ECG) moderately inhibited the histamine release. Similarly, EGCG, ECG, and EGC inhibited LTB4 release from PEC, whereas C and EC were not effective. The magnitude of the inhibitory effect on the release of these mediators of tea polyphenols was in the order of EGCG>ECG>EGC. These results indicated an important role of the triphenol structure in the inhibitory activity. Therefore, the possible antiallergic effect of tea polyphenols can be expected. Society for In Vitro Biology, 1996 mast cell nationallicence polyphenol nationallicence histamine nationallicence leukotriene nationallicence Matsuo Noritaka Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut Yamada Koji Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut Yamashita Kouhei Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut Shoji Kentaro Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut Mori Mitsuo Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut Sugano Michihiro Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 32/6(1996-06-01), 340-344 1071-2690 32:6<340 1996 32 11626 https://doi.org/10.1007/BF02722960 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02722960 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsuo Noritaka Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yamada Koji Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut NATIONALLICENCE 700 1- Yamashita Kouhei Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut NATIONALLICENCE 700 1- Shoji Kentaro Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut NATIONALLICENCE 700 1- Mori Mitsuo Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sugano Michihiro Laboratory of Food Science, Department of Food Science and Technology, Kyushu University School of Agriculture 46-09, 6-10-1 Hakozaki, Higashi-ku, 812-81, Fukuoka, Japan aut NATIONALLICENCE 773 0- In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 32/6(1996-06-01), 340-344 1071-2690 32:6<340 1996 32 11626 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer