caa a22 4500 477081339 CHVBK 20180405111450.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF02723007 doi (NATIONALLICENCE)springer-10.1007/BF02723007 WNT-mediated relocalization of dishevelled proteins [Elektronische Daten] [Susan Steitz, Michael Tsang, Daniel Sussman] Summary: TheWnt family of proto-oncogenes encodes secreted signaling proteins that are required for mouse development. TheDrosophila Wnt homolog, thewingless (Wg) segment polarity gene, mediates a signal transduction pathway in which the downstream elements appear to be conserved through evolution. One such element, thedishevelled gene product, becomes hyperphosphorylated and translocates to the plasma membrane in response to Wg (Yanagawa et al., 1995). We report here that the mouseDishevelle-1 (Dvl-1) andDishevelled-2 genes encode proteins that are differentially localized inWnt-overexpressing PC12 cell lines (PC12/Wnt). WhereasDvl-1 andDvl-2 proteins are limited to the soluble fraction of parental PC12 cells, PC12/Wnt cells display a subset ofDvl-1 protein associated with the membrane andDvl-2 protein with the cytoskeletal fraction. These results suggest a conserved role forDvl inWnt/wg signal transduction. Society for In Vitro Biology, 1996 Dishevelled nationallicence Wnt signaling nationallicence PC12 cells nationallicence signal transduction nationallicence Steitz Susan Department of Obstetrics and Gynecology, Division of Human Genetics, University of Maryland School of Medicine, 655 West Baltimore Street, 21201, Baltimore, Maryland aut Tsang Michael Department of Obstetrics and Gynecology, Division of Human Genetics, University of Maryland School of Medicine, 655 West Baltimore Street, 21201, Baltimore, Maryland aut Sussman Daniel Department of Obstetrics and Gynecology, Division of Human Genetics, University of Maryland School of Medicine, 655 West Baltimore Street, 21201, Baltimore, Maryland aut In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 32/7(1996-07-01), 441-445 1071-2690 32:7<441 1996 32 11626 https://doi.org/10.1007/BF02723007 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02723007 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Steitz Susan Department of Obstetrics and Gynecology, Division of Human Genetics, University of Maryland School of Medicine, 655 West Baltimore Street, 21201, Baltimore, Maryland aut NATIONALLICENCE 700 1- Tsang Michael Department of Obstetrics and Gynecology, Division of Human Genetics, University of Maryland School of Medicine, 655 West Baltimore Street, 21201, Baltimore, Maryland aut NATIONALLICENCE 700 1- Sussman Daniel Department of Obstetrics and Gynecology, Division of Human Genetics, University of Maryland School of Medicine, 655 West Baltimore Street, 21201, Baltimore, Maryland aut NATIONALLICENCE 773 0- In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 32/7(1996-07-01), 441-445 1071-2690 32:7<441 1996 32 11626 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer