caa a22 4500 477082009 CHVBK 20180405111452.0 cr unu---uuuuu 170330e19960201xx s 000 0 eng 10.1007/BF02723041 doi (NATIONALLICENCE)springer-10.1007/BF02723041 Growth characteristics of cells cultured from two murine models of polycystic kidney disease [Elektronische Daten] [Carolyn Rankin, Donna Ziemer, Robin Maser, Ivy Foo, James Calvet] Summary: Polycystic kidney disease (PKD) is characterized by multiple renal cysts that are lined by epithelium and filled with fluid. PKD may result from one of a number of factors, either inherited or environmental. In this study, we have compared two mouse models in which PKD results from a genetic cause. In the C57BL/6J-cpk model, the mutated gene is unknown. In the other model, an SV40 large T antigen transgene causes renal cysts. We examined cultured cells from the kidneys of these mouse models, comparing growth characteristics. Although several features of PKD lead one to expect that the epithelial cells lining the cysts would have an increased rate of proliferation in culture, we found that they did not. The implications of these findings are discussed. Society for In Vitro Biology, 1996 polycystic kidney disease nationallicence proliferation nationallicence murine models of PKD nationallicence growth rates nationallicence Rankin Carolyn Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut Ziemer Donna Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut Maser Robin Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut Foo Ivy Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut Calvet James Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 32/2(1996-02-01), 100-106 1071-2690 32:2<100 1996 32 11626 https://doi.org/10.1007/BF02723041 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02723041 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rankin Carolyn Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut NATIONALLICENCE 700 1- Ziemer Donna Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut NATIONALLICENCE 700 1- Maser Robin Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut NATIONALLICENCE 700 1- Foo Ivy Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut NATIONALLICENCE 700 1- Calvet James Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, 66160-7421, Kansas City, Kansas aut NATIONALLICENCE 773 0- In Vitro Cellular & Developmental Biology - Animal Springer-Verlag 32/2(1996-02-01), 100-106 1071-2690 32:2<100 1996 32 11626 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer