caa a22 4500 477082033 CHVBK 20180405111452.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01922413 doi (NATIONALLICENCE)springer-10.1007/BF01922413 Renal effects of a high unsaturated fat diet in renal artery stenosis in rats [Elektronische Daten] [G. Norton, A. Woodiwiss, B. Trifunovic] The renal effects of an unsaturated fat (UNSAT) diet in mild to moderate two-kidney, one-clip (2K1C) renovascular hypertension were evaluated. An UNSAT diet (37% by energy) prevented the development of hypertension compared to 2K1C rats fed a high saturated fat (SAT) (37% by energy) and a normal fat (CONTROL) (11% by energy) diet. Urinary sodium and fractional sodium excretion increased in 2K1C rats as compared to SHAM operated controls, regardless of the diet received. In the early weeks of the experiment (weeks 2-4 post-surgery to induce hypertension), an enhanced natriuresis occurred in the 2K1C UNSAT as compared to the 2K1C CONTROL and SAT diet groups. This resulted from an increase in the glomerular filtration rate (GFR in mls·min−1) as measured using the single-injection [51Cr] EDTA method (2K1C UNSAT; 1.99±0.18 versus 2K1C SAT; 1.27±0.09, p<0.02; and versus SHAM CONTROL; 1.45×0.01; p<0.02). The increased GFR was not associated with alterations in effective renal plasma flow (ERPF) as measured using the single-injection [125I] Na hippurate method. No differences in sodium excretion; GFR; ERPF or renal blood flow (microsphere technique) were noted between the 2K1C UNSAT and SAT diet groups at weeks 6-8 post-surgery, despite a continued antihypertensive effect of the UNSAT diet. Hence, the antihypertensive effect of an unsaturated fat diet in 2K1C renovascular hypertension in rats is associated with transient glomerular changes leading to an enhanced natriuresis. Birkhäuser Verlag Basel, 1996 Unsaturated dietary fats nationallicence renal hypertension nationallicence natriuresis nationallicence glomerular filtration rate nationallicence renal blood flow nationallicence Norton G. Department of Physiology, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193, Johannesburg, (South Africa) aut Woodiwiss A. Department of Physiology, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193, Johannesburg, (South Africa) aut Trifunovic B. Department of Physiology, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193, Johannesburg, (South Africa) aut Experientia Birkhäuser-Verlag 52/1(1996-01-01), 34-41 0014-4754 52:1<34 1996 52 18 https://doi.org/10.1007/BF01922413 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01922413 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Norton G. Department of Physiology, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193, Johannesburg, (South Africa) aut NATIONALLICENCE 700 1- Woodiwiss A. Department of Physiology, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193, Johannesburg, (South Africa) aut NATIONALLICENCE 700 1- Trifunovic B. Department of Physiology, University of the Witwatersrand Medical School, 7 York Road, Parktown, 2193, Johannesburg, (South Africa) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/1(1996-01-01), 34-41 0014-4754 52:1<34 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer