caa a22 4500 477082068 CHVBK 20180405111452.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01922420 doi (NATIONALLICENCE)springer-10.1007/BF01922420 Acylfulvenes, a new class of potent antitumor agents [Elektronische Daten] [T. McMorris, M. Kelner, W. Wang, M. Diaz, L. Estes, R. Taetle] Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound. Birkhäuser Verlag Basel, 1996 Acylfulvene nationallicence illudin S nationallicence sesquiterpene nationallicence antitumor agents nationallicence McMorris T. Department of Chemistry, University of California, San Diego, 92093-0506, La Jolla, California, USA aut Kelner M. Department of Pathology University of California, San Diego, 92093-0506, La Jolla, California, USA aut Wang W. Department of Chemistry, University of California, San Diego, 92093-0506, La Jolla, California, USA aut Diaz M. Department of Chemistry, University of California, San Diego, 92093-0506, La Jolla, California, USA aut Estes L. Department of Pathology University of California, San Diego, 92093-0506, La Jolla, California, USA aut Taetle R. Division of Hematology, Arizona Cancer Center, University of Arizona, 1501 N. Campbell Avenue, 95724, Tucson, Arizona, USA aut Experientia Birkhäuser-Verlag 52/1(1996-01-01), 75-80 0014-4754 52:1<75 1996 52 18 https://doi.org/10.1007/BF01922420 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01922420 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McMorris T. Department of Chemistry, University of California, San Diego, 92093-0506, La Jolla, California, USA aut NATIONALLICENCE 700 1- Kelner M. Department of Pathology University of California, San Diego, 92093-0506, La Jolla, California, USA aut NATIONALLICENCE 700 1- Wang W. Department of Chemistry, University of California, San Diego, 92093-0506, La Jolla, California, USA aut NATIONALLICENCE 700 1- Diaz M. Department of Chemistry, University of California, San Diego, 92093-0506, La Jolla, California, USA aut NATIONALLICENCE 700 1- Estes L. Department of Pathology University of California, San Diego, 92093-0506, La Jolla, California, USA aut NATIONALLICENCE 700 1- Taetle R. Division of Hematology, Arizona Cancer Center, University of Arizona, 1501 N. Campbell Avenue, 95724, Tucson, Arizona, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/1(1996-01-01), 75-80 0014-4754 52:1<75 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer