caa a22 4500 477082092 CHVBK 20180405111452.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01922414 doi (NATIONALLICENCE)springer-10.1007/BF01922414 Induction of autotomy in the American bird grasshopper Schistocerca americana (Drury) by the ecdysone agonist RH-5849 and investigation of its mode of action [Elektronische Daten] [F. Ortego, W. Bowers] The non-steroidal ecdysone agonist RH-5849 (1,2-dibenzoyl-l-tert-butylhydrazine) was found to be an effective neurotoxicant on injection into the American bird grasshopper,Schistocerca americana (Drury). Treated grasshoppers became immediately hyperactive, followed by loss of coordination, paralysis and eventually death. We also discovered that this compound induced bilateral autotomy of the metathoracic legs during the early stages of intoxication. However, no evidence of ecdysonergic or morphogenetic activities was observed. Synergism studies with neurotoxins of known mode of action suggested that RH-5849 has a mechanism of action similar to that of 4-amino pyridine, which blocks potassium channels. Birkhäuser Verlag Basel, 1996 Grasshopper nationallicence Schistocerca nationallicence ecdysone agonist nationallicence RH-5849 nationallicence autotomy nationallicence Ortego F. Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Velázquez 144, E-28006, Madrid, (Spain) aut Bowers W. Department of Entomology, University of Arizona, 85721, Tucson, Arizona, USA aut Experientia Birkhäuser-Verlag 52/1(1996-01-01), 42-50 0014-4754 52:1<42 1996 52 18 https://doi.org/10.1007/BF01922414 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01922414 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ortego F. Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Velázquez 144, E-28006, Madrid, (Spain) aut NATIONALLICENCE 700 1- Bowers W. Department of Entomology, University of Arizona, 85721, Tucson, Arizona, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/1(1996-01-01), 42-50 0014-4754 52:1<42 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer