caa a22 4500 477082114 CHVBK 20180405111452.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01922416 doi (NATIONALLICENCE)springer-10.1007/BF01922416 Evidence for suppression of immune function by insulin-like growth factor-1 in dwarf rats in vivo [Elektronische Daten] [A. Schurmann, G. Spencer, C. Berry, E. Decuypere, B. Goddeeris] These studies were undertaken to investigate the effects of increasing or decreasing IGF-1 levels on aspects of immune function in rats. Female dwarf rats were treated with recombinant human IGF-1 or with a potent sheep anti-IGF-serum. Body weight, thymus weight and spleen weight increased with IGF-1 treatment (p<0.001), while there was no effect of anti-IGF-1 treatment when compared with the appropriate normal sheep serum (NSS) treated controls. IGF-1 treatment significantly decreased WBC and RBC counts, but increased the ratio of CD4+:CD8+ T-cells. Anti-IGF-1 serum had no effect on these parameters compared with NSS. However anti-IGF-1 was associated with increased T-cell numbers, decreased natural killer cells, and enhancement of the animals' ability to produce specific IgG in response to injection of keyhole limpet haemocyanin (KLH). These results indicate that IGF-1 may suppress immune function although increasing the size of immune organs such as spleen. Birkhäuser Verlag Basel, 1996 Insulin-like growth factor-1 nationallicence thymus nationallicence spleen nationallicence lymphocytes nationallicence antibodies nationallicence immune function nationallicence Schurmann A. Ruakura Agricultural Centre, Private Bag 3123, Hamilton, (New Zealand) aut Spencer G. Ruakura Agricultural Centre, Private Bag 3123, Hamilton, (New Zealand) aut Berry C. Catholic University, Leuven, (Belgium) aut Decuypere E. Catholic University, Leuven, (Belgium) aut Goddeeris B. Catholic University, Leuven, (Belgium) aut Experientia Birkhäuser-Verlag 52/1(1996-01-01), 55-59 0014-4754 52:1<55 1996 52 18 https://doi.org/10.1007/BF01922416 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01922416 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schurmann A. Ruakura Agricultural Centre, Private Bag 3123, Hamilton, (New Zealand) aut NATIONALLICENCE 700 1- Spencer G. Ruakura Agricultural Centre, Private Bag 3123, Hamilton, (New Zealand) aut NATIONALLICENCE 700 1- Berry C. Catholic University, Leuven, (Belgium) aut NATIONALLICENCE 700 1- Decuypere E. Catholic University, Leuven, (Belgium) aut NATIONALLICENCE 700 1- Goddeeris B. Catholic University, Leuven, (Belgium) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/1(1996-01-01), 55-59 0014-4754 52:1<55 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer