caa a22 4500 477082130 CHVBK 20180405111452.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01922417 doi (NATIONALLICENCE)springer-10.1007/BF01922417 Involvement of H1 receptors in the central antinociceptive effect of histamine: Pharmacological dissection by electrophysiological analysis [Elektronische Daten] [P. Braga, E. Soldavini, A. Pecile, V. Sibilia, C. Netti] Intracerebroventricular (i.c.v.) administration of histamine (HA, 0.025-0.1 μM/rat) to arthritic rats induces a dose-related inhibition of the neuronal thalamic firing evoked by peripheral noxious stimuli. To characterize the type(s) of HA receptors involved in this depressing activity of the amine we used electrophysiological techniques to examine the effects of i.c.v. administration of H1 and H2 agonists and antagonists on the spontaneous and evoked nociceptive firing of the thalamic neurons in rats rendered arthritic by Freund's adjuvant. The H1 agonist 2-pyridylethylamine (0.4-1.0 μM/rat, i.c.v) displayed a dose-dependent antinociceptive effect very similar to that of HA, while the H2 agonist dimaprit (0.05-0.2 μM/rat, i.c.v.) did not modify thalamic firing. Neither mepyramine (H1 antagonist, 0.1 μM/rat, i.c.v.) nor zolantidine (H2 antagonist, 0.01 μM/rat, i.c.v.) modified the evoked firing of rat thalamic neurons. When administered before HA (0.1 μM/rat, i.c.v.) mepyramine but not zolantidine was able to inhibit the antinociceptive effect of HA. On the basis of the present electrophysiological results, we suggest that a specific interaction of histamine with H1 receptors may be important for its antinociceptive effect on afferent peripheral inputs to the thalamus. Birkhäuser Verlag Basel, 1996 Histamine antinociception nationallicence histamine receptors nationallicence 2-pyridylethylamine nationallicence dimaprit nationallicence mepyramine nationallicence zolantidine nationallicence Braga P. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut Soldavini E. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut Pecile A. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut Sibilia V. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut Netti C. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut Experientia Birkhäuser-Verlag 52/1(1996-01-01), 60-65 0014-4754 52:1<60 1996 52 18 https://doi.org/10.1007/BF01922417 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01922417 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Braga P. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut NATIONALLICENCE 700 1- Soldavini E. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut NATIONALLICENCE 700 1- Pecile A. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut NATIONALLICENCE 700 1- Sibilia V. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut NATIONALLICENCE 700 1- Netti C. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, I-20129, Milan, (Italy) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/1(1996-01-01), 60-65 0014-4754 52:1<60 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer