caa a22 4500 477082181 CHVBK 20180405111453.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01922418 doi (NATIONALLICENCE)springer-10.1007/BF01922418 Influence of repeated prazosin administration on cardiovascular responses in rats and rabbits [Elektronische Daten] [S. Hui, B. Qiu] Prazosin was injected i.v. at a dose of 50 μg/kg every 2 h for 8 h in conscious rats. Its hypotensive action significantly declined. A similar effect was also observed in rabbits pretreated with prazosin (40 μg/kg, i.v.) every 1 h for 4 h. In prazosin-treated rabbits, the total peripheral resistance became less responsive to phentolamine stimulation. Repeated prazosin administration abolished its ability to block receptors in a model of anococcygue muscle contraction after noradrenaline (NA) stimulation. The α-adrenoceptors in anococcygue muscle exhibited lower pD2 to NA and lower pA2 to prazosin in prazosin-treated rats. The results demonstrate that repeated prazosin administration reduces the effectiveness of α-adrenoceptors blockers. Birkhäuser Verlag Basel, 1996 Prazosin nationallicence tolerance nationallicence blood pressure nationallicence rats nationallicence rabbits nationallicence Hui S. Studies in Biomedical and Health Science, School of Professional, and Continuing Education, Knowles Building, The University of Hong Kong, Pokfulam Road, Hong Kong aut Qiu B. Shantou University Medical College, (China) aut Experientia Birkhäuser-Verlag 52/1(1996-01-01), 66-69 0014-4754 52:1<66 1996 52 18 https://doi.org/10.1007/BF01922418 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01922418 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hui S. Studies in Biomedical and Health Science, School of Professional, and Continuing Education, Knowles Building, The University of Hong Kong, Pokfulam Road, Hong Kong aut NATIONALLICENCE 700 1- Qiu B. Shantou University Medical College, (China) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/1(1996-01-01), 66-69 0014-4754 52:1<66 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer