caa a22 4500 47708219X CHVBK 20180405111453.0 cr unu---uuuuu 170330e19960101xx s 000 0 eng 10.1007/BF01922423 doi (NATIONALLICENCE)springer-10.1007/BF01922423 Synthesis and cannabinoid receptor binding activity of conjugated triene anandamide, a novel eicosanoid [Elektronische Daten] [M. Wise, K. Soderstrom, T. Murray, W. Gerwick] A polyenoic fatty-acid isomerase (PFI) from a red marine alga was used to convert anandamide (5Z,8Z,11Z,14Z-eicosatetraenoyl-N-ethanolamide) to the 5Z,7E,9E,14Z-eicosatetraenoyl-N-ethanolamide isomer. This novel eicosanoid, termed conjugated triene anandamide (CTA), was assessed for its ability to bind to the cannabinoid receptor in rat brain membrane preparations. CTA is a high affinity cannabimimetic substance whose novel structure provides new insight into structure-activity relationships of cannabinoid receptor ligands. These experiments illustrate the utility of enzymes isolated from marine organisms in the development of pharmacological probes. Birkhäuser Verlag Basel, 1996 Cannabinoid receptor nationallicence polyenoic fatty-acid isomerase nationallicence marine enzyme nationallicence anandamide nationallicence red algae nationallicence Wise M. Department of Biochemistry and Biophysics, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut Soderstrom K. College of Pharmacy, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut Murray T. College of Pharmacy, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut Gerwick W. Department of Biochemistry and Biophysics, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut Experientia Birkhäuser-Verlag 52/1(1996-01-01), 88-92 0014-4754 52:1<88 1996 52 18 https://doi.org/10.1007/BF01922423 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01922423 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wise M. Department of Biochemistry and Biophysics, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut NATIONALLICENCE 700 1- Soderstrom K. College of Pharmacy, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut NATIONALLICENCE 700 1- Murray T. College of Pharmacy, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut NATIONALLICENCE 700 1- Gerwick W. Department of Biochemistry and Biophysics, Oregon State University, Pharmacy Building 203, 97331, Corvallis, Oregon, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/1(1996-01-01), 88-92 0014-4754 52:1<88 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer