caa a22 4500 477082211 CHVBK 20180405111453.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF01969724 doi (NATIONALLICENCE)springer-10.1007/BF01969724 Platelet aggregation is inhibited by phycolectins [Elektronische Daten] [K. Matsubara, H. Sumi, K. Hori] Lectins from four marine algal species were examined for interaction with human platelets. The lectin designated hypnin A, from the red algaHypnea japonica, inhibited adenosine diphosphate (ADP)-or collagen-induced human platelet aggregation in a dose-dependent manner. Complete inhibition was observed at concentrations of 100 and 5 μg/ml of the lectin with, ADP (2 μM) and collagen (0.2 μg/ml)-induced platelet aggregation, respectively. At the inhibitory concentration of 0.5 to 100 μg/ml, the lectin did not induce aggregation of resting platelets. Lectins from the other three algal species also inhibited ADP-induced human platelet aggregation. These results indicate that the algal lectins are a new group of inhibitors and may be useful to study glycoconjugates on platelet membranes and to design novel platelet aggregation inhibitors. Birkhäuser Verlag, 1996 Lectin nationallicence hemagglutinin nationallicence platelet nationallicence aggregation nationallicence inhibition nationallicence Matsubara K. Department of Nutritional Science Faculty of Health and Welfare Science, Okayama Prefectural University, 719-11, Soja, Okayama, (Japan) aut Sumi H. Department of Nutritional Science Faculty of Health and Welfare Science, Okayama Prefectural University, 719-11, Soja, Okayama, (Japan) aut Hori K. Faculty of Applied Biological Science, Hiroshima University, Kagamiyama 1-4-4, 738, Higashi-Hiroshima, (Japan) aut Experientia Birkhäuser-Verlag 52/6(1996-06-01), 540-543 0014-4754 52:6<540 1996 52 18 https://doi.org/10.1007/BF01969724 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01969724 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Matsubara K. Department of Nutritional Science Faculty of Health and Welfare Science, Okayama Prefectural University, 719-11, Soja, Okayama, (Japan) aut NATIONALLICENCE 700 1- Sumi H. Department of Nutritional Science Faculty of Health and Welfare Science, Okayama Prefectural University, 719-11, Soja, Okayama, (Japan) aut NATIONALLICENCE 700 1- Hori K. Faculty of Applied Biological Science, Hiroshima University, Kagamiyama 1-4-4, 738, Higashi-Hiroshima, (Japan) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/6(1996-06-01), 540-543 0014-4754 52:6<540 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer