caa a22 4500 477082432 CHVBK 20180405111453.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF01969738 doi (NATIONALLICENCE)springer-10.1007/BF01969738 The use of cyclophosphamide as an enhancer of the vaccine against foot-and-mouth disease [Elektronische Daten] [E. Portiansky, P. González, R. Laguens] The immunization of biungulate animals with killed foot-and-mouth disease virus (FMDV) requires periodic vaccinations due to a low vaccine immunogenicity. Therefore, FMDV antigens need to be combined with adjuvants such as aluminum hydroxide, saponin or oil emulsions. Animal handling for periodic inoculations, and the repeated doses of vaccines that have to be administered increase the commercialization costs. Moreover, the use of adjuvants may induce adverse effects. In the present work we show that it is possible to increase the life span of neutralizing antibodies in serum when a single dose of cyclophosphamide (Cy) is administered four days before vaccination with aluminum hydroxidesaponin FMDV vaccine. Birkhäuser Verlag, 1996 Cyclophosphamide nationallicence foot-and-mouth disease nationallicence adjuvant nationallicence vaccine nationallicence Portiansky E. Cátedra de Patología General Veterinaria, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118, 1900, La Plata, (Argentina) aut González P. Cátedra de Patología ‘B', Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, (Argentina) aut Laguens R. Cátedra de Patología ‘B', Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, (Argentina) aut Experientia Birkhäuser-Verlag 52/6(1996-06-01), 605-607 0014-4754 52:6<605 1996 52 18 https://doi.org/10.1007/BF01969738 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01969738 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Portiansky E. Cátedra de Patología General Veterinaria, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, 60 y 118, 1900, La Plata, (Argentina) aut NATIONALLICENCE 700 1- González P. Cátedra de Patología ‘B', Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, (Argentina) aut NATIONALLICENCE 700 1- Laguens R. Cátedra de Patología ‘B', Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 60 y 120, 1900, La Plata, (Argentina) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/6(1996-06-01), 605-607 0014-4754 52:6<605 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer