caa a22 4500 477082440 CHVBK 20180405111453.0 cr unu---uuuuu 170330e19960601xx s 000 0 eng 10.1007/BF01969742 doi (NATIONALLICENCE)springer-10.1007/BF01969742 Inhibition of invasion and intraerythrocytic development of Plasmodium falciparum by kinase inhibitors [Elektronische Daten] [A. Dluzewski, C. Garcia] We have examined the effects of seven protein kinase inhibitors (staurosporine, genistein, methyl 2,5-dihydroxycinnamate, tyrphostins B44 and B46, lavendustin A and R03) on the erythrocytic cycle of the malaria parasite,Plasmodium falciparum. One (staurosporine) strongly inhibits serine/threonine kinases, but the remainder all exhibit a strong preference for tyrosine kinases. We have been able to discriminate between effects on invasion and on intraerythrocytic development. All reagents impeded development of intraerythrocytic parasites, though at widely differing concentrations, from the sub-micromolar to the millimolar. Several inhibitors, including staurosporine, also reduced invasion. The phosphatase inhibitor, okadaic acid, had a strong inhibitory effect both on invasion and development. The regulation of malaria development by phosphorylation or dephosphorylation reactions at several points in the blood-stage cycle is implied. Birkhäuser Verlag, 1996 Malaria nationallicence Plasmodium falciparum nationallicence kinase inhibitors nationallicence okadaic acid nationallicence Dluzewski A. Muscle and Cell Motility Unit, King's College, Medical Research Council, 26-29 Drury Lane, WC2B 5RL, London, UK aut Garcia C. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, (Brasil) aut Experientia Birkhäuser-Verlag 52/6(1996-06-01), 621-623 0014-4754 52:6<621 1996 52 18 https://doi.org/10.1007/BF01969742 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01969742 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dluzewski A. Muscle and Cell Motility Unit, King's College, Medical Research Council, 26-29 Drury Lane, WC2B 5RL, London, UK aut NATIONALLICENCE 700 1- Garcia C. Departamento de Parasitologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, (Brasil) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/6(1996-06-01), 621-623 0014-4754 52:6<621 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer