caa a22 4500 477082505 CHVBK 20180405111453.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01938878 doi (NATIONALLICENCE)springer-10.1007/BF01938878 Neidhart M. Department of Rheumatology, University Hospital Zurich, CH-8091, Zurich, (Switzerland) aut Effects of Freund's complete adjuvant on the dirunal rhythms of neuroendocrine processes and ornithine decarboxylase activity in various tissues of male rats [Elektronische Daten] [M. Neidhart] The aim of this study was to investigate the effects of Freund's complete adjuvant (FCA) on the diurnal rhythms of hormonal parameters in serum and ornithine decarboxylase (ODC) activity in various tissues of male rats. On days 1-2 after FCA, increase of ODC activity (used to evaluate the level of activation) was observed in the hypothalamus, pituitary gland, adrenal medulla, adrenal cortex, liver and lymphoid tissues, while the ODC activity in the kidney was reduced. This was accompanied by an increase in serum corticosterone. On days 3-4 after FCA, ODC activity remained elevated in the pituitary gland, liver and lymphoid tissues, while the ODC activity in the testes and panceas was reduced; kidney ODC activity returned to baseline. This was associated with increased serum levels of prolactin (Prl) and luteinizing hormone, but decreased growth hormone, testosterone and insulin. The increase in ODC activity in the thymus, as well as the reduced ODC activity in the testes and kidney, can be obtained with paraffin. Furthermore, bromocryptine microcapsules (CBLA) reduced the FCA-induced increase of ODC activity in the pituitary gland, liver and lymphoid tissues (days 3-4) but did not affect the changes in other tissues. The increase in ODC activity in the pituitary gland, liver and lymphoid tissues is specific for FCA. A role for Prl in the induction of ODC in liver and lymphoid tissues is suggested by the fact that CBLA suppresses this enhancement. Birkhäuser Verlag, 1996 Freund's complete adjuvant nationallicence diurnal rhythms nationallicence ornithine decarboxylase nationallicence prolactin nationallicence Experientia Birkhäuser-Verlag 52/9(1996-09-01), 900-908 0014-4754 52:9<900 1996 52 18 https://doi.org/10.1007/BF01938878 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01938878 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Neidhart M. Department of Rheumatology, University Hospital Zurich, CH-8091, Zurich, (Switzerland) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/9(1996-09-01), 900-908 0014-4754 52:9<900 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer