caa a22 4500 477082653 CHVBK 20180405111454.0 cr unu---uuuuu 170330e19960901xx s 000 0 eng 10.1007/BF01938870 doi (NATIONALLICENCE)springer-10.1007/BF01938870 Ochsner M. Physics Department, Ciba-Geigy Ltd., CH-4002, Basle, (Switzerland) aut The action of the peptidoleukotriene LTD4 on intracellular calcium in rat mesangial cells [Elektronische Daten] [M. Ochsner] The dose-dependent effect of CGP 45715A on the LTD4-induced Ca2+ response of glomerular mesangial cells has been studied. Our results demonstrate that the LTD4-dependent increase in the cytosolic Ca2+ concentration primarily involves an InsP3-mediated release of Ca2+ from intracellular storage sites and to a minor extent an enhanced influx of Ca2+ through receptor-operated Ca2+ channels located in the plasma membrane. The action of CGP 45715A on the Ca2+ response is an inhibitory one and is convincingly explained by a displacement of LTD4 from its receptor site(s). The contractile effect of LTD4 on pulmonary smooth muscle is proposed to be mainly caused by a receptor-mediated hydrolysis of phosphatidylinositol-4,5-bisphosphate. Birkhäuser Verlag, 1996 Asthma nationallicence LTD4 nationallicence CGP 45715A nationallicence LTD4-receptor antagonist nationallicence cytosolic Ca2+ transient nationallicence Experientia Birkhäuser-Verlag 52/9(1996-09-01), 856-864 0014-4754 52:9<856 1996 52 18 https://doi.org/10.1007/BF01938870 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01938870 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Ochsner M. Physics Department, Ciba-Geigy Ltd., CH-4002, Basle, (Switzerland) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/9(1996-09-01), 856-864 0014-4754 52:9<856 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer