caa a22 4500 477082777 CHVBK 20180405111454.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF01925580 doi (NATIONALLICENCE)springer-10.1007/BF01925580 Experimental liver fibrosis induced in rats receiving high doses of alcohol and alternating between regular and vitamin-depleted diets [Elektronische Daten] [H. Hirano, T. Hirano, K. Hirata, M. Tamura, T. Yamaura, T. Hamada] Liver fibrosis was induced in rats by simulating human alcoholic eating and drinking patterns. Alcohol addiction was established by gradually increasing the ethanol concentration in the drinking water; salts were added at the terminal stage. The hepatocytes of rats receiving alcohol concentrations exceeding 50% (v/v) (similar to vodka) exhibited alcoholic hyaline (Mallory bodies). Alcoholic liver fibrosis was induced by alternating between regular and autoclaved (vitamin-depleted) diets, simulating the irregular eating habits of human alcoholics. In the livers of rats receiving 70% (v/v) ethanol (comparable to absinthe) with 25% saline and fed the alternating diets, pericellular fibrosis was induced. No significant difference in calorie intake between control and alcohol rats was detected except when rats underwent drinking bouts (heavy drinking phase). This indicates that neither a high-fat diet nor a choline-depleted diet is necessary to induce the alcoholic fibrosis seen in human alcoholics. Birkhäuser Verlag, 1996 Vitamins nationallicence alcoholic hyaline nationallicence alternative diet nationallicence fibrogenesis nationallicence Hirano H. Department of Biochemistry, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut Hirano T. Department of Molecular Biology, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut Hirata K. Department of Surgery, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut Tamura M. Department of Biochemistry, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut Yamaura T. Department of Psychiatry, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut Hamada T. Department of Surgical Pathology, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut Experientia Birkhäuser-Verlag 52/7(1996-07-01), 710-715 0014-4754 52:7<710 1996 52 18 https://doi.org/10.1007/BF01925580 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01925580 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hirano H. Department of Biochemistry, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut NATIONALLICENCE 700 1- Hirano T. Department of Molecular Biology, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut NATIONALLICENCE 700 1- Hirata K. Department of Surgery, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut NATIONALLICENCE 700 1- Tamura M. Department of Biochemistry, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut NATIONALLICENCE 700 1- Yamaura T. Department of Psychiatry, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut NATIONALLICENCE 700 1- Hamada T. Department of Surgical Pathology, University of Occupational and Environmental Health, 807, Yahatanishi Kitakyushu, (Japan) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/7(1996-07-01), 710-715 0014-4754 52:7<710 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer