caa a22 4500 477082785 CHVBK 20180405111454.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF01925571 doi (NATIONALLICENCE)springer-10.1007/BF01925571 Relationship of phosphatidylcholine to hydrophobic surfactant on rat intestinal chylomicron secretion [Elektronische Daten] [J. Rodgers, D. Beeler, P. Tso] Hydrophobic surfactants such as Poloxalene inhibit triglyceride secretion into lymph by enterocytes. The inhibitory effect of these agents on triglyceride secretion is reversed when lipid presented for absorption is exclusively in the form of phosphatidylcholine (PC) and not triglyceride. The present investigation performed in conscious mesenteric lymph fistula rats was designed to determine whether various mixtures of triglyceride and PC given intraduodenally with Poloxalene would also reverse the inhibitory effect of Poloxalene on triglyceride secretion into lymph. A 50-50 mixture of triolein (TO) and PC resulted in normal triglyceride secretion into lymph. However, when the mixture of lipids was 75-25, TO to PC, results for triglyceride recovery in lymph were considerably reduced. The transport rate for triglyceride into lymph was not as depressed, however, as observed for Poloxalene treated rats given lipid for absorption basically in the triglyceride form. Substitution of phosphatidylethanolamine for PC had no beneficial effect on triglyceride secretion in Poloxalene treated rats. It is concluded that PC can reverse the inhibitory effect of Poloxalene on triglyceride secretion into lymph even when considerable amounts of triglyceride along with PC are presented for absorption. Birkhäuser Verlag, 1996 Hydrophobic surfactant nationallicence phosphatidyncholine nationallicence triglyceride nationallicence small intestine nationallicence lipid absorption nationallicence Rodgers J. Department of Medicine, Albany Medical College, A-48, 12208, Albany, New York, USA aut Beeler D. Department of Biochemistry, Albany Medical College, A-48, 12208, Albany, New York, USA aut Tso P. Department of Physiology, Louisiana State University, 71130, Shreveport, Louisiana, USA aut Experientia Birkhäuser-Verlag 52/7(1996-07-01), 671-676 0014-4754 52:7<671 1996 52 18 https://doi.org/10.1007/BF01925571 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01925571 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Rodgers J. Department of Medicine, Albany Medical College, A-48, 12208, Albany, New York, USA aut NATIONALLICENCE 700 1- Beeler D. Department of Biochemistry, Albany Medical College, A-48, 12208, Albany, New York, USA aut NATIONALLICENCE 700 1- Tso P. Department of Physiology, Louisiana State University, 71130, Shreveport, Louisiana, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/7(1996-07-01), 671-676 0014-4754 52:7<671 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer