caa a22 4500 477082858 CHVBK 20180405111454.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF01925569 doi (NATIONALLICENCE)springer-10.1007/BF01925569 Resuscitation of cadaveric livers from non-heart-beating donors after warm ischemic insult: a novel technique tested in the rat [Elektronische Daten] [T. Minor, H. Klauke, W. Isselhard] Clinical liver transplantation has become the therapy of choice in end-stage liver disease, but the limited availability of suitable donor organs still impedes its widespread application. In order to increase the availability of donor organs for liver transplantation, it would be advantageous if ischemically damaged livers could be resuscitated from cadavers in which the heart has stopped beating. A method for doing this has been developed in a rat model. Compared to livers excised from rats in which the heart is still beating, severe deteriorations of tissue integrity and functional performance were evident in predamaged livers after cold preservation without supplementary treatment. A treatment of those livers which included an antioxidant rinse with superoxide dismutase, and venous vascular insufflation of gaseous oxygen during preservation, completely prevented tissue alterations upon reperfusion, and promoted a functional recovery of the livers, making them comparable to organs harvested from heart-beating donors. Birkhäuser Verlag, 1996 Non-heart-beating donor nationallicence liver nationallicence oxygen nationallicence persufflation nationallicence aerobic ischemia nationallicence transplantation nationallicence preservation nationallicence resuscitation nationallicence viability nationallicence Minor T. Institute for Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, D-50931, Cologne, (Germany) aut Klauke H. Institute for Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, D-50931, Cologne, (Germany) aut Isselhard W. Institute for Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, D-50931, Cologne, (Germany) aut Experientia Birkhäuser-Verlag 52/7(1996-07-01), 661-663 0014-4754 52:7<661 1996 52 18 https://doi.org/10.1007/BF01925569 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01925569 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Minor T. Institute for Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, D-50931, Cologne, (Germany) aut NATIONALLICENCE 700 1- Klauke H. Institute for Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, D-50931, Cologne, (Germany) aut NATIONALLICENCE 700 1- Isselhard W. Institute for Experimental Medicine, University of Cologne, Robert-Koch-Strasse 10, D-50931, Cologne, (Germany) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/7(1996-07-01), 661-663 0014-4754 52:7<661 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer