caa a22 4500 477082874 CHVBK 20180405111454.0 cr unu---uuuuu 170330e19960701xx s 000 0 eng 10.1007/BF01925572 doi (NATIONALLICENCE)springer-10.1007/BF01925572 Amylin given by central or peripheral routes decreases gastric emptying and intestinal transit in the rat [Elektronische Daten] [G. clementi, A. Caruso, V. Cutuli, E. de Bernardis, A. Prato, M. Amico-Roxas] The effect of rat amylin on gastric emptying and intestinal transit in the rat was examined. Amylin administered intracerebroventricularly (1, 2, 2.5 or 4 μg/rat) produced the maximal decrease in gastric emptying and intestinal transit at the dose of 2.5 μg/rat. Higher doses produced a lower effect. Peripheral administration (25, 50 or 100 μg/kg) produced dose-dependent effects. Pre-treatment with neostigmine blocked the effect of amylin when it was centrally injected, while the effect of amylin given peripherally was partially reduced. Pre-treatment with domperidone decreased the inhibitory effect of peripherally injected amylin, but no effect was observed when the peptide was centrally injected. Birkhäuser Verlag, 1996 Amylin nationallicence gastric emptying nationallicence intestinal transit nationallicence neostigmine nationallicence domperidone nationallicence clementi G. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut Caruso A. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut Cutuli V. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut de Bernardis E. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut Prato A. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut Amico-Roxas M. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut Experientia Birkhäuser-Verlag 52/7(1996-07-01), 677-679 0014-4754 52:7<677 1996 52 18 https://doi.org/10.1007/BF01925572 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01925572 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- clementi G. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut NATIONALLICENCE 700 1- Caruso A. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut NATIONALLICENCE 700 1- Cutuli V. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut NATIONALLICENCE 700 1- de Bernardis E. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut NATIONALLICENCE 700 1- Prato A. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut NATIONALLICENCE 700 1- Amico-Roxas M. Institute of Pharmacology, University of Catania, School of Medicine, Viale Andrea Doria 6, I-95125, Catania, (Italy) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/7(1996-07-01), 677-679 0014-4754 52:7<677 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer