caa a22 4500 477082955 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01952103 doi (NATIONALLICENCE)springer-10.1007/BF01952103 Cytosolic factors in mitochondrial protein import [Elektronische Daten] [K. Mihara, T. Omura] In vitro import studies have confirmed the participation of cytosolic protein factors in the import of various precursor proteins into mitochondria. The requirement for extramitochondrial adenosine triphosphate for the import of a group of precursor proteins seems to be correlated with the chaperone activity of the cytosolic protein factors. One of the cytosolic protein factors is hsp70, which generally recognizes and binds unfolded proteins in the cytoplasm. Hsp70 keeps the newly synthesized mitochondrial precursor proteins in import-competent unfolded conformations. Another cytosolic protein factor that has been characterized is mitochondrial import stimulation factor (MSF), which seems to be specific to mitochondrial precursor proteins. MSF recognizes the mitochondrial precursor proteins, forms a complex with them and targets them to the receptors on the outer surface of mitochondria. Birkhäuser Verlag, 1996 Mitochondrial protein import nationallicence cytosolic factors nationallicence hsp70 nationallicence targeting factor nationallicence presequence-binding factor (PBF) nationallicence mitochondrial import stimulation factor (MSF) nationallicence MSF-dependent import nationallicence Mihara K. Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, 812, Fukuoka, (Japan) aut Omura T. Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, 812, Fukuoka, (Japan) aut Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1063-1068 0014-4754 52:12<1063 1996 52 18 https://doi.org/10.1007/BF01952103 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01952103 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mihara K. Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, 812, Fukuoka, (Japan) aut NATIONALLICENCE 700 1- Omura T. Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, 812, Fukuoka, (Japan) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1063-1068 0014-4754 52:12<1063 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer