caa a22 4500 477082963 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01952111 doi (NATIONALLICENCE)springer-10.1007/BF01952111 Myc: a single gene controls both proliferation and apoptosis in mammalian cells [Elektronische Daten] [L. Desbarats, A. Schneider, D. Müller, A. Bürgin, M. Eilers] c-myc was discovered as the cellular homologue of the transduced oncogene of several avian retroviruses. The gene encodes a transcription factor, which forms a heteromeric protein complex with a partner protein termed Max. In mammalian cells, Myc is a central regulator of cell proliferation and links external signals to the cell cycle machinery. Myc also induces cells to undergo apoptosis, unless specific signals provided either by cytokines or by oncogenes block the apoptotic pathway. Recent progress sheds light both on the factors regulating the function and expression of Myc and on the downstream targets in the cell cycle. Together, these findings suggest the existence of a novel signal transduction pathway regulating both apoptosis and proliferation. Birkhäuser Verlag, 1996 c- myc nationallicence max nationallicence oncogene nationallicence transcription nationallicence cell cycle nationallicence apoptosis nationallicence Desbarats L. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut Schneider A. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut Müller D. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut Bürgin A. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut Eilers M. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1123-1129 0014-4754 52:12<1123 1996 52 18 https://doi.org/10.1007/BF01952111 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01952111 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Desbarats L. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut NATIONALLICENCE 700 1- Schneider A. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut NATIONALLICENCE 700 1- Müller D. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut NATIONALLICENCE 700 1- Bürgin A. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut NATIONALLICENCE 700 1- Eilers M. Zentrum für Molekulare Biologie Heidelberg (ZMBH), Im Neuenheimer Feld 282, D-69120, Heidelberg, (Germany) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1123-1129 0014-4754 52:12<1123 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer