caa a22 4500 47708298X CHVBK 20180405111455.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01952114 doi (NATIONALLICENCE)springer-10.1007/BF01952114 Molecular genetics of the peptidyl transferase center and the unusual Var1 protein in yeast mitochondrial ribosomes [Elektronische Daten] [T. Mason, C. Pan, M. Sanchirico, K. Sirum-Connolly] Mitochondria posses their own ribosomes responsible for the synthesis of a small number of proteins encoded by the mitochondrial genome. In yeast,Saccharomyces cerevisiae, the two ribosomal RNAs and a single ribosomal protein, Varl, are products of mitochondrial genes, and the remaining approximately 80 ribosomal proteins are encoded in the nucleus. The mitochondrial translation system is dispensable in yeast, providing an excellent experimental model for the molecular genetic analysis of the fundamental properties of ribosomes in general as well as adaptations required for the specialized role of ribosomes in mitochondria. Recent studies of the peptidyl transferase center, one of the most highly conserved functional centers of the ribosome, and the Varl protein, an unusual yet essential protein in the small ribosomal subunit, have provided new insight into conserved and divergent features of the mitochondrial ribosome. Berkhäuser Verlag Basel, 1996 Saccharomyces cerevisiae nationallicence mitochondrial ribosomes nationallicence peptidyl transferase nationallicence Varl ribosomal protein nationallicence gene relocation nationallicence posttranscriptional rRNA modification nationallicence Mason T. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut Pan C. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut Sanchirico M. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut Sirum-Connolly K. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1148-1157 0014-4754 52:12<1148 1996 52 18 https://doi.org/10.1007/BF01952114 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01952114 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Mason T. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut NATIONALLICENCE 700 1- Pan C. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut NATIONALLICENCE 700 1- Sanchirico M. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut NATIONALLICENCE 700 1- Sirum-Connolly K. Department of Biochemistry and Molecular Biology, University of Massachusetts, 01003, Amherst, Massachusetts, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1148-1157 0014-4754 52:12<1148 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer