caa a22 4500 477083005 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01952098 doi (NATIONALLICENCE)springer-10.1007/BF01952098 Bacterial protein toxins and cell vesicle trafficking [Elektronische Daten] [C. Montecucco, E. Papini, G. Schiavo] A group of bacterial protein toxins interfere with vesicular trafficking inside cells. Clostridial neurotoxins affect mainly the highly regulated fusion of neurotransmitter- and hormone-containing vesicles with the plasma membrane. They cleave the three SNARE proteins: VAMP, SNAP-25 and syntaxin, and this selective proteolysis results in a blockade of exocytosis. TheHelicobacter pylori cytotoxin is implicated in the pathogenesis of gastroduodenal ulcers. It causes a progressive and extensive vacuolation of cells followed by necrosis, after a cytotoxin-induced alteration of membrane trafficking by late endosomes. Vacuoles originate from this compartment in a rab7-dependent process and swell because they are acidic and accumulate membrane-permeant amines. Birkhäuser Verlag, 1996 Tetanus nationallicence botulism nationallicence neurotoxins nationallicence proteases nationallicence exocytosis nationallicence endosomes nationallicence membrane fusion nationallicence Montecucco C. Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Università di Padova, Via Trieste 75, I-35121, Padova, (Italy) aut Papini E. Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Università di Padova, Via Trieste 75, I-35121, Padova, (Italy) aut Schiavo G. Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA aut Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1026-1032 0014-4754 52:12<1026 1996 52 18 https://doi.org/10.1007/BF01952098 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01952098 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Montecucco C. Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Università di Padova, Via Trieste 75, I-35121, Padova, (Italy) aut NATIONALLICENCE 700 1- Papini E. Centro CNR Biomembrane and Dipartimento di Scienze Biomediche, Università di Padova, Via Trieste 75, I-35121, Padova, (Italy) aut NATIONALLICENCE 700 1- Schiavo G. Cellular Biochemistry and Biophysics Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, New York, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1026-1032 0014-4754 52:12<1026 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer