caa a22 4500 477083013 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01952107 doi (NATIONALLICENCE)springer-10.1007/BF01952107 The plasma membrane calcium pump: Recent developments and future perspectives [Elektronische Daten] [E. Carafoli, E. Garcia-Martin, D. Guerini] The Ca2+ pump of the plasma membrane (PMCA) is regulated by a number of agents. The most important is calmodulin (CaM), which binds to a domain located in the C-terminal portion of the pump, removing it from an autoinhibitory site next to the active site. The CaM-binding domain is preceded by an acidic sequence which contains a hidden signal for endoplasmic reticulum (ER) retention. Chimeras of the PMCA and endoplasmic reticulum (SERCA) pumps have revealed the presence of a strong signal for ER retention in the first 45 residues of the SERCA pump. Four gene products of the PMCA pump are known: two of them (1 and 4) are ubiquitously expressed, two (2 and 3) are specific for nerve cells and may be induced by their activation. Mutagenesis work has identified four residues in three of the transmembrane domains of the pump which may be components of the trans-protein Ca2+ path. The mutation of two of these residues alters the membrane targeting of the pump. Birkhäuser Verlag, 1996 Calcium nationallicence ATPase nationallicence calmodulin nationallicence ion pumps nationallicence Carafoli E. Inst. for Biochemistry III, ETH Zurich, Universitätsstrasse 16, CH-8092, Zurich, (Switzerland) aut Garcia-Martin E. Inst. for Biochemistry III, ETH Zurich, Universitätsstrasse 16, CH-8092, Zurich, (Switzerland) aut Guerini D. Inst. for Biochemistry III, ETH Zurich, Universitätsstrasse 16, CH-8092, Zurich, (Switzerland) aut Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1091-1100 0014-4754 52:12<1091 1996 52 18 https://doi.org/10.1007/BF01952107 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01952107 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carafoli E. Inst. for Biochemistry III, ETH Zurich, Universitätsstrasse 16, CH-8092, Zurich, (Switzerland) aut NATIONALLICENCE 700 1- Garcia-Martin E. Inst. for Biochemistry III, ETH Zurich, Universitätsstrasse 16, CH-8092, Zurich, (Switzerland) aut NATIONALLICENCE 700 1- Guerini D. Inst. for Biochemistry III, ETH Zurich, Universitätsstrasse 16, CH-8092, Zurich, (Switzerland) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1091-1100 0014-4754 52:12<1091 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer