caa a22 4500 477083048 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19961201xx s 000 0 eng 10.1007/BF01952112 doi (NATIONALLICENCE)springer-10.1007/BF01952112 Fox T. Section of Genetics and Development, Cornell University, Biotechnology Building, 14853-2703, Ithaca, New York, USA aut Translational control of endogenous and recoded nuclear genes in yeast mitochondria: Regulation and membrane targeting [Elektronische Daten] [T. Fox] Mitochondrial gene expression in yeast,Saccharomyces cerevisiae, depends on translational activation of individual mRNAs by distinct proteins encoded in the nucleus. These nuclearly coded mRNA-specific translational activators are bound to the inner membrane and function to mediate the interaction between mRNAs and mitochondrial ribosomes. This complex system, found to date only in organelles, appears to be an adaptation for targeting the synthesis of mitochondrially coded integral membrane proteins to the membrane. In addition, mRNA-specific translational activation is a rate-limiting step used to modulate expression of at least one mitochondrial gene in response to environmental conditions. Direct study of mitochondrial gene regulation and the targeting of mitochondrially coded proteins in vivo will now be possible using synthetic genes inserted into mtDNA that encode soluble reporter/passenger proteins. Birkhäuser Verlag, 1996 Saccharomyces cerevisiae nationallicence mitochondria nationallicence mRNA-specific translational activation nationallicence synthetic genes nationallicence gene regulation nationallicence Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1130-1135 0014-4754 52:12<1130 1996 52 18 https://doi.org/10.1007/BF01952112 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01952112 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Fox T. Section of Genetics and Development, Cornell University, Biotechnology Building, 14853-2703, Ithaca, New York, USA aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/12(1996-12-01), 1130-1135 0014-4754 52:12<1130 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer