caa a22 4500 477083129 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01920715 doi (NATIONALLICENCE)springer-10.1007/BF01920715 Chronic sensory denervation reduces thrombin-stimulated endothelin release from aortic endothelial cells [Elektronische Daten] [P. Milner, G. Burnstock] The long-term (trophic) influence of perivascular nerves on the endothelium was investigated by measuring changes in thrombin-stimulated release of the potent vasoconstrictor, endothelin, after selective chronic denervation. Rat pups were treated with either guanethidine or capsaicin to destroy sympathetic or sensory nerves, respectively. The abdominal aortas from the rats at three months of age (5 pooled per experiment) were incubated with 4U thrombin/ml in medium for 24 h at 37°C, and the amount of endothelin released from the preparation determined by immunoassay. After neonatal sensory denervation there was a significant reduction in the thrombinstimulated release of endothelin compared to the controls (0.012±0.012 (4) compared to 0.063±0.012 (6), pmol/cm2/24 h, p<0.02). There was no change in endothelin release after sympathetic denervation. In summary, sensory nerves play a trophic role in the expression of endothelin in endothelial cells of the intima. Birkhäuser Verlag, 1996 Sympathectomy nationallicence sensory denervation nationallicence endothelin nationallicence endothelium nationallicence plasticity nationallicence Milner P. Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, Gower Street, WC1E 6BT, London, UK aut Burnstock G. Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, Gower Street, WC1E 6BT, London, UK aut Experientia Birkhäuser-Verlag 52/3(1996-03-01), 242-244 0014-4754 52:3<242 1996 52 18 https://doi.org/10.1007/BF01920715 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920715 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Milner P. Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 700 1- Burnstock G. Department of Anatomy and Developmental Biology and Centre for Neuroscience, University College London, Gower Street, WC1E 6BT, London, UK aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/3(1996-03-01), 242-244 0014-4754 52:3<242 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer