caa a22 4500 477083218 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01920714 doi (NATIONALLICENCE)springer-10.1007/BF01920714 L-arginine and pancreatic islet blood flow in anesthetized rats [Elektronische Daten] [A. Svensson, L. Jansson] The aim of the present study was to see if L-arginine, which induces insulin release and is a precursor of the endothelial-derived relaxing factor nitric oxide, affects whole pancreatic and/or islet blood flow. For this purpose, anesthetized male Sprague-Dawley rats were injected intravenously with either saline or L-arginine (25, 100 or 250 mg/kg body weight). All doses of arginine caused a slight increase in blood glucose concentration, while the highest dose (250 mg/kg body weight) also increased insulin concentration. However, no changes in either mean arterial blood pressure, whole pancreatic or islet blood flow could be discerned with any of the doses of arginine used. It is concluded that insulin release is not necessarily associated with an increased islet blood perfusion. Birkhäuser Verlag, 1996 Pancreatic islets nationallicence islet blood flow nationallicence arginine nationallicence insulin secretion nationallicence Svensson A. Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, S-751 23, Uppsala, Sweden aut Jansson L. Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, S-751 23, Uppsala, Sweden aut Experientia Birkhäuser-Verlag 52/3(1996-03-01), 239-241 0014-4754 52:3<239 1996 52 18 https://doi.org/10.1007/BF01920714 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920714 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Svensson A. Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, S-751 23, Uppsala, Sweden aut NATIONALLICENCE 700 1- Jansson L. Department of Medical Cell Biology, Uppsala University, Biomedical Center, PO Box 571, S-751 23, Uppsala, Sweden aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/3(1996-03-01), 239-241 0014-4754 52:3<239 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer