caa a22 4500 477083250 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01920708 doi (NATIONALLICENCE)springer-10.1007/BF01920708 Arresting the mitotic oscillator and the control of cell proliferation: insights from a cascade model for cdc2 kinase activation [Elektronische Daten] [A. Goldbeter, J. Guilmot] We consider a minimal cascade model previously proposed11 for the mitotic oscillator driving the embryonic cell division cycle. The model is based on a bicyclic phosphorylation-dephosphorylation cascade involving cyclin and cdc2 kinase. By constructing stability diagrams showing domains of periodic behavior as a function of the maximum rates of the kinases and phosphatases involved in the two cycles of the cascade, we investigate the role of these converter enzymes in the oscillatory mechanism. Oscillations occur when the balance of kinase and phosphatase rates in each cycle is in a range bounded by two critical values. The results suggest ways to arrest the mitotic oscillator by altering the maximum rates of the converter enzymes. These results bear on the control of cell proliferation. Birkhäuser Verlag, 1996 Cell cycle nationallicence G1/S and G2/M transitions nationallicence metaphase arrest nationallicence cell proliferation nationallicence biochemical oscillations nationallicence phosphorylation-dephosphorylation cascade nationallicence Goldbeter A. Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, C.P. 231, B-1050, Brussels, Belgium aut Guilmot J. Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, C.P. 231, B-1050, Brussels, Belgium aut Experientia Birkhäuser-Verlag 52/3(1996-03-01), 212-216 0014-4754 52:3<212 1996 52 18 https://doi.org/10.1007/BF01920708 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920708 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldbeter A. Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, C.P. 231, B-1050, Brussels, Belgium aut NATIONALLICENCE 700 1- Guilmot J. Faculté des Sciences, Université Libre de Bruxelles, Campus Plaine, C.P. 231, B-1050, Brussels, Belgium aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/3(1996-03-01), 212-216 0014-4754 52:3<212 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer