caa a22 4500 477083269 CHVBK 20180405111455.0 cr unu---uuuuu 170330e19960301xx s 000 0 eng 10.1007/BF01920712 doi (NATIONALLICENCE)springer-10.1007/BF01920712 Miyachi Y. Department of Physiology, Toho University School of Medicine, Ohmori-Nishi 5-21-16, Ota-ku, 143, Tokyo, Japan aut Marked depression of radiation-induced emesis by olfactory bulbectomy or pre-exposure using low doses [Elektronische Daten] [Y. Miyachi] Acute emetic response to relatively low-doses of X-irradiation on suncus (Suncus murinus) was examined. The behaviors recorded for each subject, using a video-cassette recorder system, were (1) the number of emesis, during exposure to a dose of 3.0 Gy; (2) emesis threshold. Results showed that the emetic threshold was observed at 0.85 Gy, and the number of radioemesis during exposure was 29. However, the observed threshold dose became 2.22 Gy following olfactory bulbectomy. The emetic number decreased significantly (p<0.01), and reached a value one-fourth of the sham-control. The bulbectomized suncus showed a resistance to X-irradiation. Furthermore, I examined whether the animals could also acquire radio-resistance when they were subjected to a brief of dose X-ray (0.3 Gy) prior to a exposure to 3.0 Gy. Results showed that brief pre-exposure increased the observed threshold, a pattern that was exactly the same as shown in the bulbectomized animals. Increasing the pre-exposure dose further to 0.45-0.60 Gy, however, resulted in the complete disappearance of the effect. These results suggest that only the mice pre-irradiated with 0.30 Gy acquired resistance to radiation-induced emesis. Birkhäuser Verlag, 1996 X-irradiation nationallicence suncus nationallicence olfactory bulbectomy nationallicence emesis nationallicence acute radiation sickness nationallicence radio-resistance nationallicence Experientia Birkhäuser-Verlag 52/3(1996-03-01), 230-233 0014-4754 52:3<230 1996 52 18 https://doi.org/10.1007/BF01920712 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01920712 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Miyachi Y. Department of Physiology, Toho University School of Medicine, Ohmori-Nishi 5-21-16, Ota-ku, 143, Tokyo, Japan aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/3(1996-03-01), 230-233 0014-4754 52:3<230 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer