caa a22 4500 477083765 CHVBK 20180405111457.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF01919537 doi (NATIONALLICENCE)springer-10.1007/BF01919537 Phosphotyrosine protein phosphatase and diabetic pregnancy: an association between low molecular weight acid phosphatase and degree of glycemic control [Elektronische Daten] [F. Gloria-Bottini, G. Gerlini, N. Lucarini, P. Borgiani, A. Amante, M. La Torre, E. Antonacci, E. Bottini] Low molecular weight acid phosphatase encoded by the highly polymorphic locus ACP 1 is a member of the protein-tyrosin phosphatase family (PTPases) which plays an essential role in the control of receptor signalling through phosphotyrosine pathways. Recent experiments have shown that purified rat liver ACP, corresponding to human ACP1, is able to hydrolyze a phosphotyrosine-containing synthetic peptide corresponding to the 1146-1158 sequence of the human insulin receptor, and shows a high affinity for it. This prompted us to analyze the degree of glycemic control in relation to ACP1 genetic variability in a sample of 214 diabetic pregnant women including IDDM, NIDDM and gestational diabetes. The ACP1 genotype was also determined in 482 non-diabetic pregnant women. In diabetic women glycemic levels in thelast trimester of pregnancy appear to be significantly associated with the ACP1 genotype, and correlated positively with ACP1 enzymatic activity. The data suggest that quantitative variations of ACP1 may influence the clincal mainifestations of diabetic disorders, and call for further studies on the role of this enzyme in the modulation of insulin-receptor phosphotyrosine pathways. Birkhäuser Verlag, 1996 Tyrosine phosphatase nationallicence ACP1 nationallicence diabetic pregnancy nationallicence Gloria-Bottini F. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut Gerlini G. Department of Child Health, 1st University of Rome, School of Medicine, Rome, (Italy) aut Lucarini N. Laboratory of Genetics, University of Camerino, School of Science, Camerino, (Italy) aut Borgiani P. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut Amante A. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut La Torre M. Department of Pediatrics, USSL Penne, Stanza 852, Via Orazio Raimondo, I-00173, Rome, (Italy) aut Antonacci E. Center of Diabetology, USSL, Penne, (Italy) aut Bottini E. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut Experientia Birkhäuser-Verlag 52/4(1996-04-01), 340-343 0014-4754 52:4<340 1996 52 18 https://doi.org/10.1007/BF01919537 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01919537 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gloria-Bottini F. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut NATIONALLICENCE 700 1- Gerlini G. Department of Child Health, 1st University of Rome, School of Medicine, Rome, (Italy) aut NATIONALLICENCE 700 1- Lucarini N. Laboratory of Genetics, University of Camerino, School of Science, Camerino, (Italy) aut NATIONALLICENCE 700 1- Borgiani P. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut NATIONALLICENCE 700 1- Amante A. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut NATIONALLICENCE 700 1- La Torre M. Department of Pediatrics, USSL Penne, Stanza 852, Via Orazio Raimondo, I-00173, Rome, (Italy) aut NATIONALLICENCE 700 1- Antonacci E. Center of Diabetology, USSL, Penne, (Italy) aut NATIONALLICENCE 700 1- Bottini E. Chair of Human Development, University of Rome-Torvergata, School of Medicine, Via di Tor Vergata, 135, C.A.P., I-0133, Rome, (Italy) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/4(1996-04-01), 340-343 0014-4754 52:4<340 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer