caa a22 4500 477083897 CHVBK 20180405111457.0 cr unu---uuuuu 170330e19960401xx s 000 0 eng 10.1007/BF01919539 doi (NATIONALLICENCE)springer-10.1007/BF01919539 Central nicotinic receptor blockade inhibits emotionally conditioned pressor responses in rats [Elektronische Daten] [T. Kubo, Y. Katsumata, R. Fukumori, K. Taguchi, Y. Hagiwara] A conditioned stimulus previously paired with electric footshock produced an increase in blood pressure in conscious, freely moving rats. The conditioned pressor response was reproducible. Intracerebroventricular injection of the nicotinic receptor antagonists hexamethonium (1-10 μg) or pentolinium (10 μg) but not the muscarinic receptor antagonist methylatropine (3 μg) produced an inhibition of the conditioned pressor response, whereas intraarterial injection of hexamethonium (10 μg) did not affect the response. Intraventricular injection of the cholinesterase inhibitor physostigmine (3-10 μg) produced an enhancement of the conditioned pressor response. These results are consistent with the possibility that central nicotinic receptors play a role in the expression of the emotionally conditioned pressor response in rats. Birkhäuser Verlag, 1996 Central nicotinic receptors nationallicence central muscarinic receptors nationallicence classical conditioning nationallicence conditioned pressor response nationallicence central acetylcholine nationallicence Kubo T. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut Katsumata Y. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut Fukumori R. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut Taguchi K. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut Hagiwara Y. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut Experientia Birkhäuser-Verlag 52/4(1996-04-01), 348-352 0014-4754 52:4<348 1996 52 18 https://doi.org/10.1007/BF01919539 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01919539 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kubo T. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut NATIONALLICENCE 700 1- Katsumata Y. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut NATIONALLICENCE 700 1- Fukumori R. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut NATIONALLICENCE 700 1- Taguchi K. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut NATIONALLICENCE 700 1- Hagiwara Y. Department of Pharmacology, Showa College of Pharmaceutical Sciences, Machida, 194, Tokyo, (Japan) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/4(1996-04-01), 348-352 0014-4754 52:4<348 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer