caa a22 4500 477083978 CHVBK 20180405111457.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01923988 doi (NATIONALLICENCE)springer-10.1007/BF01923988 Lack of tolerance development to tumor necrosis factor α inside the central nervous system [Elektronische Daten] [J. Goldbach, J. Roth, B. Störr, E. Zeisberger] Tumor necrosis factor α (TNFα) was repeatedly microinfused into the lateral ventricle of guinea pig brains at a dose of 200 ng, 4 times within 150 min, at intervals of 3 days. In comparison to guinea pigs infused with solvent according to the same time schedule, the animals responded to TNFα with pronounced fevers. The quantity of the fever response was the same after each of the 4 microinfusions of TNFα. Three days after the last infusion of TNFα or solvent all animals received an intramuscular injection of bacterial lipopolysaccharide (LPS). The fever in response to LPS was the same in both groups. Thus, the reported development of tolerance to repeated systemic administration of TNFα1−3 does not develop inside the blood-brain barrier. Also, the febrile response to LPS is not influenced by repeated central pre-treatment with TNFα, whereas repeated peripheral treatment does have an effect. Birkhäuser Verlag Basel, 1996 Tumor necrosis factor α nationallicence body temperature nationallicence fever nationallicence tolerance development nationallicence central nervous system nationallicence radiotelemetry nationallicence guinea pig nationallicence Goldbach J. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut Roth J. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut Störr B. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut Zeisberger E. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut Experientia Birkhäuser-Verlag 52/8(1996-08-01), 774-777 0014-4754 52:8<774 1996 52 18 https://doi.org/10.1007/BF01923988 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923988 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Goldbach J. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut NATIONALLICENCE 700 1- Roth J. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut NATIONALLICENCE 700 1- Störr B. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut NATIONALLICENCE 700 1- Zeisberger E. Physiologisches Institut, Klinikum der Justus-Liebig-Universität, Aulweg 129, D-35392, Gießen, (Germany) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/8(1996-08-01), 774-777 0014-4754 52:8<774 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer