caa a22 4500 477084079 CHVBK 20180405111457.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01923994 doi (NATIONALLICENCE)springer-10.1007/BF01923994 Molecular evidence for increased hematopoietic proliferation in the spleen of the b/b laboratory rat [Elektronische Daten] [S. Savković, S. Pavlović, T. Mitrović, M. Joksimović, J. Marjanović, V. Glišin, Z. Popović] The splenomegaly and the appearance of a significant number of CFU-E (erythroid colony-forming units) and BFU-E1 (erythroid burst-forming units) in the Belgrade laboratory rat (b/b) spleen prompted us to analyse further the molecular evidence for increased hematopoietic proliferation in the b/b spleen. Messenger RNAs (mRNAs) specific for globins, proteins for iron transport and deposition and the band 3 protein were used in rat erythropoietic tissues as markers for proliferation and erythroid differentiation. In the b/b spleen, all mRNAs analysed display an erythroid-specific pattern of expression. This analysis also revealed an enhanced level of mRNA for ferritin in the +/b spleen, whereas erythrocyte-specific mRNA production was normal. Birkhäuser Verlag Basel, 1996 b/b Rat nationallicence +/b rat nationallicence α-globin nationallicence β-globin nationallicence band 3 protein nationallicence transferrin receptor nationallicence ferritin nationallicence Savković S. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut Pavlović S. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut Mitrović T. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut Joksimović M. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut Marjanović J. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut Glišin V. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut Popović Z. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut Experientia Birkhäuser-Verlag 52/8(1996-08-01), 807-811 0014-4754 52:8<807 1996 52 18 https://doi.org/10.1007/BF01923994 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923994 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Savković S. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut NATIONALLICENCE 700 1- Pavlović S. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut NATIONALLICENCE 700 1- Mitrović T. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut NATIONALLICENCE 700 1- Joksimović M. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut NATIONALLICENCE 700 1- Marjanović J. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut NATIONALLICENCE 700 1- Glišin V. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut NATIONALLICENCE 700 1- Popović Z. Institute of Molecular Genetics and Genetic Engineering, Vojvode Stepe 283, P. O. Box 794, 11001, Beograd, (Yugoslavia) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/8(1996-08-01), 807-811 0014-4754 52:8<807 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer