caa a22 4500 477084125 CHVBK 20180405111458.0 cr unu---uuuuu 170330e19960801xx s 000 0 eng 10.1007/BF01923997 doi (NATIONALLICENCE)springer-10.1007/BF01923997 Glucose formation from methylglyoxal in hepatocytes from streptozotocin-induced diabetic mice: the effect of insulin [Elektronische Daten] [M. Kalapos, P. Riba, T. Garzó, J. Mandl] Acetol and methylglyoxal are intermediates of the intrahepatic metabolism of acetone leading to pyruvate formation. In hepatocytes prepared from fasted streptozotocin-induced diabetic mice, net glucose production could be measured from methylglyoxal but not from acetone or acetol. Insulin increased glucose formation from methylglyoxal in a concentration-dependent manner, whereas it was ineffective when pyruvate was used as substrate. Drug oxidation, as evidenced byp-aminophenol formation from aniline, was enhanced by methylglyoxal, and insulin proved to be stimulatory in this case as well. It is concluded that insulin might be involved in the regulation of glucose formation from methylglyoxal, but its mode of action is not yet clear. Birkhäuser Verlag Basel, 1996 Acetone nationallicence acetol nationallicence methylglyoxal nationallicence pyruvate nationallicence gluconeogenesis nationallicence drug oxidation nationallicence insulin nationallicence hepatocyte (mouse) nationallicence Kalapos M. First Institute of Biochemistry, Semmelweis University Medical School, Budapest, (Hungary) aut Riba P. Department of Pharmacology, Semmelweis University Medical School, Budapest, (Hungary) aut Garzó T. First Institute of Biochemistry, Semmelweis University Medical School, Budapest, (Hungary) aut Mandl J. First Institute of Biochemistry, Semmelweis University Medical School, Budapest, (Hungary) aut Experientia Birkhäuser-Verlag 52/8(1996-08-01), 827-830 0014-4754 52:8<827 1996 52 18 https://doi.org/10.1007/BF01923997 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01923997 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kalapos M. First Institute of Biochemistry, Semmelweis University Medical School, Budapest, (Hungary) aut NATIONALLICENCE 700 1- Riba P. Department of Pharmacology, Semmelweis University Medical School, Budapest, (Hungary) aut NATIONALLICENCE 700 1- Garzó T. First Institute of Biochemistry, Semmelweis University Medical School, Budapest, (Hungary) aut NATIONALLICENCE 700 1- Mandl J. First Institute of Biochemistry, Semmelweis University Medical School, Budapest, (Hungary) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/8(1996-08-01), 827-830 0014-4754 52:8<827 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer