caa a22 4500 477084214 CHVBK 20180405111458.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01919312 doi (NATIONALLICENCE)springer-10.1007/BF01919312 The regulation of trehalose metabolism in insects [Elektronische Daten] [A. Becker, P. Schlöder, J. Steele, G. Wegener] Trehalose is a non-reducing disaccharide comprising two glucose molecules. It is present in high concentration as the main haemolymph (blood) sugar in insects. The synthesis of trehalose in the fat body (an organ analogous in function to a combination of liver and adipose tissue in vertebrates) is stimulated by neuropeptides (hypertrehalosaemic hormones), released from the corpora cardiaca, a neurohaemal organ associated with the brain. The peptides cause a decrease in the content of fructose 2,6-bisphosphate in fat body cells. Fructose 2,6-bisphosphate, acting synergistically with AMP, is a potent activator of the glycolytic enzyme 6-phosphofructokinase-1 and a strong inhibitor of the gluconeogenic enzyme fructose 1,6-bisphosphatase. This indicates that fructose 2,6-bisphosphate is a key metabolic signal in the regulation of trehalose synthesis in insects. Trehalose is hydrolysed by trehalase (E.C. 3.2.1.28). The activity of this enzyme is regulated in flight muscle, but the mechanism by which this is achieved is unknown. Trehalase from locust, flight muscle is a glycoprotein bound to membranes of the microsomal fraction. The enzyme can be activated by detergents in vitro and by short flight intervals in vivo, which indicates that changes in the membrane environment modulate trehalase activity under physiological conditions. Birkhäuser Verlag, 1996 Trehalose nationallicence insect haemolymph nationallicence neuropeptides nationallicence insect fat body nationallicence fructose 2,6-bisphosphate nationallicence insect flight muscle nationallicence regulation of trehalase nationallicence Becker A. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut Schlöder P. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut Steele J. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut Wegener G. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut Experientia Birkhäuser-Verlag 52/5(1996-05-01), 433-439 0014-4754 52:5<433 1996 52 18 https://doi.org/10.1007/BF01919312 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01919312 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Becker A. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut NATIONALLICENCE 700 1- Schlöder P. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut NATIONALLICENCE 700 1- Steele J. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut NATIONALLICENCE 700 1- Wegener G. Institut für Zoologie, Johannes-Gutenberg-Universität, Saarstrasse 21, D-55099, Mainz, (Germany) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/5(1996-05-01), 433-439 0014-4754 52:5<433 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer