caa a22 4500 477084222 CHVBK 20180405111458.0 cr unu---uuuuu 170330e19960501xx s 000 0 eng 10.1007/BF01919318 doi (NATIONALLICENCE)springer-10.1007/BF01919318 Accumulation of purine catabolites in solid tumors exposed to therapeutic hyperthermia [Elektronische Daten] [M. Busse, P. Vaupel] Intensified adenosine triphosphate (ATP) degradation following therapeutic hyperthermia is often observed in solid tumors. As a result, accumulation of purine catabolites can be expected together with formation of protons at several stages during degradation to the final product, uric acid. Proton formation in turn can contribute to the development of heat-induced acidosis. Furthermore, oxidation of hypoxanthine and xanthine may result in generation of reactive oxygen species, which may lead to DNA damage, lipid peroxidation and protein denaturation, thus also contributing to heat-induced cytotoxicity. In hyperthermia experiments a tumor-size-dependent, significant increase in the levels of the following catabolites has been demonstrated: Σ[IMP+GMP] (sum of guanosine and inosine monophosphate levels), inosine, hypoxanthine, xanthine and uric acid, along with a drop in ATP and guanosine triphosphate (GTP) levels. These data suggest that formation of reactive oxygen species and protons during purine degradation may indeed play a significant role in the antitumor effect of hyperthermia. Birkhäuser Verlag, 1996 Tumor hyperthermia nationallicence ATP degradation nationallicence purine catabolism nationallicence hypoxanthine nationallicence xanthine nationallicence uric acid nationallicence reactive oxygen species nationallicence tumor acidosis nationallicence Busse M. Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D-55099, Mainz, (Germany) aut Vaupel P. Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D-55099, Mainz, (Germany) aut Experientia Birkhäuser-Verlag 52/5(1996-05-01), 469-473 0014-4754 52:5<469 1996 52 18 https://doi.org/10.1007/BF01919318 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01919318 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Busse M. Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D-55099, Mainz, (Germany) aut NATIONALLICENCE 700 1- Vaupel P. Institute of Physiology and Pathophysiology, University of Mainz, Duesbergweg 6, D-55099, Mainz, (Germany) aut NATIONALLICENCE 773 0- Experientia Birkhäuser-Verlag 52/5(1996-05-01), 469-473 0014-4754 52:5<469 1996 52 18 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer